3.0
Summary
| Name |  ARHGEF4View Modifications |
| Full Name | Rho guanine nucleotide exchange factor 4 |
| Synonyms | APC-stimulated guanine nucleotide exchange factor 1, Asef, Asef1 | KIAA1112 |
| Primary ID | Q9NR80 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRC | up-regulates 
phosphorylation
|
ARHGEF4 | 0.318 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGEF4 | up-regulates activity
guanine nucleotide exchange factor
|
RHOA | 0.653 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGEF4 | up-regulates activity
guanine nucleotide exchange factor
|
CDC42 | 0.729 |
| Publications: | 1 | Organism: | Homo Sapiens | |