+ |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
PDGFC |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254272 |
|
|
Rattus norvegicus |
Aortic Smooth Muscle |
pmid |
sentence |
15247255 |
The PDGF family of ligands is comprised of A, B, C, and D chains. Here, we provide the first functional characterization of the PDGF-C promoter. We examined 797 bp of the human PDGF-C promoter and identified several putative recognition elements for Sp1, Ets Egr-1, and Smad.|These findings thus demonstrate that PDGF-C transcription, activated by FGF-2, is mediated by Egr-1 and its upstream kinase ERK.|Egr-1 and Sp1 specifically bind the PDGF-C promoter |
|
Publications: |
1 |
Organism: |
Rattus Norvegicus |
+ |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
PDGFC |
0.254 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254268 |
|
|
Rattus norvegicus |
Aortic Smooth Muscle |
pmid |
sentence |
15247255 |
The PDGF family of ligands is comprised of A, B, C, and D chains. Here, we provide the first functional characterization of the PDGF-C promoter. We examined 797 bp of the human PDGF-C promoter and identified several putative recognition elements for Sp1, Ets Egr-1, and Smad.|These findings thus demonstrate that PDGF-C transcription, activated by FGF-2, is mediated by Egr-1 and its upstream kinase ERK.|Egr-1 and Sp1 specifically bind the PDGF-C promoter |
|
Publications: |
1 |
Organism: |
Rattus Norvegicus |