3.0
Summary
| Name |  STK36
|
| Full Name | Serine/threonine-protein kinase 36 |
| Synonyms | Fused homolog | KIAA1278 |
| Primary ID | Q9NRP7 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia. |
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binding
polyubiquitination