Relation Results

Summary

Name Microprocessor complex
Primary ID SIGNOR-C356
Links CPX-3080
Type complex
Formed by DROSHA, DGCR8
Relations 6
Pathways YAP/TAZ regulation

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Type: Score: Layout: SPV 
0.5580.9250.40.70.7230.925DDX17Microprocessor complexDGCR8mir-10bNcRNA_processingDDX5DROSHA

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Relations
Regulator
Mechanism
target
score ℹ
+ DDX17up-regulates activity img/direct-activation.png binding Microprocessor complex 0.558
Identifier Residue Sequence Organism Cell Line
SIGNOR-277660 Homo sapiens
pmid sentence
In addition, nuclear YAP has also been found to regulate miRNA processing. Nuclear YAP/TAZ bind and sequester DEAD box helicase 17 (DDX17) (also known as p72) to repress its association with Microprocessor, a complex that regulates miRNA processing (Figure 3B).
Publications: 1 Organism: Homo Sapiens
+ DGCR8form complex img/form-complex.png binding Microprocessor complex 0.925
Identifier Residue Sequence Organism Cell Line
SIGNOR-264849 Homo sapiens HaCaT Cell
pmid sentence
Microprocessor minimally comprises the ribonuclease DROSHA and its double-stranded RNA-binding partner DGCR8 (Denli et al., 2004; Gregory et al., 2004). Microprocessor recognizes pri-miRNA through the stem-loop (Zeng et al., 2005) and the stem-loop-ssRNA junction (Han et al., 2006), and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA.
Publications: 1 Organism: Homo Sapiens
+ Microprocessor complexup-regulates quantity img/direct-activation.png post transcriptional regulation mir-10b 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-275661
pmid sentence
Both the phosphorylation and sumoylation of DDX5 enhance the formation of a DDX5/Drosha/DGCR8 complex, thus promoting microRNA-10b processing.
Publications: 1
+ Microprocessor complexup-regulates img/indirect-activation.png NcRNA_processing 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264850
pmid sentence
Microprocessor minimally comprises the ribonuclease DROSHA and its double-stranded RNA-binding partner DGCR8 (Denli et al., 2004; Gregory et al., 2004). Microprocessor recognizes pri-miRNA through the stem-loop (Zeng et al., 2005) and the stem-loop-ssRNA junction (Han et al., 2006), and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA.
Publications: 1
+ DDX5up-regulates activity img/direct-activation.png binding Microprocessor complex 0.723
Identifier Residue Sequence Organism Cell Line
SIGNOR-275659
pmid sentence
Both the phosphorylation and sumoylation of DDX5 enhance the formation of a DDX5/Drosha/DGCR8 complex, thus promoting microRNA-10b processing.
Publications: 1
+ DROSHAform complex img/form-complex.png binding Microprocessor complex 0.925
Identifier Residue Sequence Organism Cell Line
SIGNOR-264848 Homo sapiens HaCaT Cell
pmid sentence
Microprocessor minimally comprises the ribonuclease DROSHA and its double-stranded RNA-binding partner DGCR8 (Denli et al., 2004; Gregory et al., 2004). Microprocessor recognizes pri-miRNA through the stem-loop (Zeng et al., 2005) and the stem-loop-ssRNA junction (Han et al., 2006), and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA.
Publications: 1 Organism: Homo Sapiens
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