Relation Results

Summary

Name UBQLN4
Full Name Ubiquilin-4
Synonyms Ataxin-1 interacting ubiquitin-like protein, A1Up, Ataxin-1 ubiquitin-like-interacting protein A1U, Connexin43-interacting protein of 75 kDa, CIP75 | C1orf6, CIP75, UBIN
Primary ID Q9NRR5
Links - -
Type protein
Relations 2
Function Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:2 ...
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Type: Score: Layout: SPV 
0.20.2ATMUBQLN4MRE11

Modifications Tables

Relations

Regulator
Mechanism
target
score
+ up-regulates activity img/direct-activation.png phosphorylation UBQLN4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265076 Ser318 GNSDSSSsQPLRTEN Homo sapiens U2-OS Cell
pmid sentence
These results suggest that UBQLN4 phosphorylation on S318 is functionally important for its role in the DSB response.>Particularly HRR is dependent on ATM activity (Dietlein et al., 2014). Here, we showed that UBQLN4 is an ATM substrate and that DSB sealing is markedly impaired in UBQLN4-depleted cells. HRR depends on a 5′-3′ DSB end resection, which is initiated by the MRE11 nuclease
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MRE11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265077 Homo sapiens U2-OS Cell
pmid sentence
These data suggest that MRE11 is one of probably many UBQLN4 interaction partners. >Particularly HRR is dependent on ATM activity (Dietlein et al., 2014). Here, we showed that UBQLN4 is an ATM substrate and that DSB sealing is markedly impaired in UBQLN4-depleted cells. HRR depends on a 5′-3′ DSB end resection, which is initiated by the MRE11 nuclease
Publications: 1 Organism: Homo Sapiens
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