| + |
DNMT3A | down-regulates quantity by repression 
transcriptional regulation
|
FGF21 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262200 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29091029 |
Unbiased gene profiling studies revealed Fgf21 as a key negatively regulated Dnmt3a target gene in adipocytes with concordant changes in DNA methylation at the Fgf21 promoter region. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF4 | up-regulates quantity by expression 
transcriptional regulation
|
FGF21 |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253748 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22233381 |
These results add FGF21 gene induction to the transcriptional programme initiated by increased levels of ATF4 and offer a new mechanism for the induction of the FGF21 gene expression under nutrient deprivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF2 | up-regulates quantity by expression
transcriptional regulation
|
FGF21 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253743 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 25055037 |
The increased production of reactive oxygen species, subsequent induction of p38 MAPK (mitogen-activated protein kinase) and activation of an ATF2 (activating transcription factor 2)-binding site at the proximal promoter region of the FGF21 gene was found to be a major mechanism linking mitochondrial dysfunction with enhanced FGF21 gene transcription in myogenic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FGF21
- 
- 