4.0
Summary
| Name |  CISH
|
| Full Name | Cytokine-inducible SH2-containing protein |
| Synonyms | CIS, CIS-1, Protein G18, Suppressor of cytokine signaling, SOCS | G18 |
| Primary ID | Q9NSE2 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
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transcriptional regulation
transcriptional regulation