| + |
LYN | up-regulates activity 
phosphorylation
|
PAG1 |
0.714 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262898 |
Tyr317 |
EEEISAMySSVNKPG |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 16920712 |
Here we show that Lyn interacts with C-terminal Src kinase-binding protein (Cbp), an adaptor protein that recruits negative regulators C-terminal Src kinase (Csk)/Csk-like protein-tyrosine kinase (Ctk). Lyn phosphorylated Cbp on several tyrosine residues, including Tyr314, which recruited Csk/Ctk to suppress Lyn kinase activity.Thus, a single phosphotyrosine residue on Cbp coordinates a two-phase process involving distinct negative regulatory pathways to inactivate, then degrade, Lyn. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262893 |
Tyr387 |
SEEPEPDyEAIQTLN |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 16920712 |
Here we show that Lyn interacts with C-terminal Src kinase-binding protein (Cbp), an adaptor protein that recruits negative regulators C-terminal Src kinase (Csk)/Csk-like protein-tyrosine kinase (Ctk). Lyn phosphorylated Cbp on several tyrosine residues, including Tyr314, which recruited Csk/Ctk to suppress Lyn kinase activity.Thus, a single phosphotyrosine residue on Cbp coordinates a two-phase process involving distinct negative regulatory pathways to inactivate, then degrade, Lyn. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262899 |
Tyr417 |
LVPKENDyESISDLQ |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 16920712 |
Here we show that Lyn interacts with C-terminal Src kinase-binding protein (Cbp), an adaptor protein that recruits negative regulators C-terminal Src kinase (Csk)/Csk-like protein-tyrosine kinase (Ctk). Lyn phosphorylated Cbp on several tyrosine residues, including Tyr314, which recruited Csk/Ctk to suppress Lyn kinase activity.Thus, a single phosphotyrosine residue on Cbp coordinates a two-phase process involving distinct negative regulatory pathways to inactivate, then degrade, Lyn. |
|
| Publications: |
3 |
Organism: |
Chlorocebus Aethiops |
3.0
PAG1
- 
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