3.0
Summary
| Name |  MCUB
|
| Full Name | Calcium uniporter regulatory subunit MCUb, mitochondrial |
| Synonyms | MCUb, Coiled-coil domain-containing protein 109B | CCDC109B |
| Primary ID | Q9NWR8 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MCUB | form complex 
binding
|
MCU_MICUB_variant | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |