Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271590 |
|
|
Homo sapiens |
Natural Killer Cell |
pmid |
sentence |
16709802 |
We demonstrated that both UbcH7 and UbcH8 bind to full-length NKLAM. We demonstrated decreased protein expression and enhanced ubiquitination of URKL-1 in the presence of NKLAM. These data indicate that NKLAM is a RING finger protein that binds Ubcs and has as one of its substrates, URKL-1, thus defining this cytolytic protein as an E3 ubiquitin ligase. |
|