Summary

Name ELOVL2
Full Name Elongation of very long chain fatty acids protein 2
Synonyms 3-keto acyl-CoA synthase ELOVL2, ELOVL fatty acid elongase 2, ELOVL FA elongase 2, Very long chain 3-ketoacyl-CoA synthase 2, Very long chain 3-oxoacyl-CoA synthase 2 | SSC2
Primary ID Q9NXB9
Links - -
Type protein
Relations 2
Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification palmitoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification 3-hydroxyoctadecanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens