Relation Results

Summary

Name TUBA8
Full Name Tubulin alpha-8 chain
Synonyms Alpha-tubulin 8, Tubulin alpha chain-like 2 | TUBAL2
Primary ID Q9NY65
Links - -
Type protein
Relations 5
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeab ...
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Type: Score: Layout: SPV 
0.20.3110.2440.2520.7NUMA1TUBA8TTLATAT1Elongator complexNeuron_migration

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Relations
Regulator
Mechanism
target
score ℹ
+ NUMA1up-regulates img/direct-activation.png binding TUBA8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-116826 Homo sapiens
pmid sentence
Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.
Publications: 1 Organism: Homo Sapiens
+ TTLdown-regulates img/direct_inhibition.png tyrosination TUBA8 0.311
Identifier Residue Sequence Organism Cell Line
SIGNOR-176930 Homo sapiens
pmid sentence
Tubulin tyrosine ligase (ttl) adds a c-terminal tyr to __tubulin as part of a tyrosination/detyrosination cycle present in most eukaryotic cells. / ttl inhibits spontaneous tubulin polymerization
Publications: 1 Organism: Homo Sapiens
+ ATAT1up-regulates quantity by stabilization img/direct-activation.png acetylation TUBA8 0.244
Identifier Residue Sequence Organism Cell Line
SIGNOR-272250 in vitro
pmid sentence
Alpha-Tubulin acetyltransferase (alphaTAT1) is the major α-tubulin lysine-40 (K40) acetyltransferase in mammals, nematodes, and protozoa, and its activity plays a conserved role in several microtubule-based processes.|The tubulin subunits of microtubules are acetylated, and lysine-40 (K40) of the alpha-tubulin subunit has been identified as an important conserved site of microtubule acetylation (6–8). This modification is considered a hallmark of stable, long-lived microtubules
Publications: 1 Organism: In Vitro
+ Elongator complexup-regulates activity img/direct-activation.png acetylation TUBA8 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-269721 Homo sapiens HEK-293 Cell
pmid sentence
Elongator Subunits Interact with the Microtubules and Are Required for Proper Acetylation of α-Tubulin.
Publications: 1 Organism: Homo Sapiens
+ TUBA8up-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269729 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
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