| + |
CyclinK/CDK12 | up-regulates activity 
phosphorylation
|
POLR2A |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273104 |
Ser1616 |
TPQSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273097 |
Ser1623 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273092 |
Ser1644 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273090 |
Ser1651 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273091 |
Ser1665 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273096 |
Ser1672 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273095 |
Ser1693 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273094 |
Ser1714 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273098 |
Ser1721 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273093 |
Ser1735 |
SPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273108 |
Ser1763 |
TPTSPSYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273107 |
Ser1784 |
TPTSPNYsPTSPSYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273105 |
Ser1861 |
TPTSPKYsPTSPKYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273087 |
Ser1868 |
SPTSPKYsPTSPKYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273089 |
Ser1875 |
SPTSPKYsPTSPTYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273085 |
Ser1878 |
SPKYSPTsPTYSPTT |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273102 |
Ser1882 |
SPTSPTYsPTTPKYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273103 |
Ser1889 |
SPTTPKYsPTSPTYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273101 |
Ser1896 |
SPTSPTYsPTSPVYT |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273106 |
Ser1910 |
TPTSPKYsPTSPTYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273100 |
Ser1917 |
SPTSPTYsPTSPKYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273088 |
Ser1924 |
SPTSPKYsPTSPTYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273099 |
Ser1931 |
SPTSPTYsPTSPKGS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273084 |
Ser1941 |
SPKGSTYsPTSPGYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273086 |
Ser1948 |
SPTSPGYsPTSPTYS |
Homo sapiens |
MV-4-11 Cell |
| pmid |
sentence |
| 32917631 |
Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related and structurally similar kinases, and biochemical assays have demonstrated that both have POLII C-terminal domain (CTD) kinase activity and the ability to phosphorylate the Ser2 residue of the repetitive CTD heptad sequence |
|
| Publications: |
25 |
Organism: |
Homo Sapiens |
| + |
CyclinK/CDK12 | up-regulates activity
phosphorylation
|
PAK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273111 |
Thr134 |
LKFYDSNtVKQKYLS |
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 32483448 |
Mechanistically, CDK12 directly binds to and phosphorylates PAK2 at T134/T169 to activate MAPK signaling pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273112 |
Thr169 |
TEAPAVVtEEEDDDE |
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 32483448 |
Mechanistically, CDK12 directly binds to and phosphorylates PAK2 at T134/T169 to activate MAPK signaling pathway |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CCNK | form complex 
binding
|
CyclinK/CDK12 |
0.941 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
We identified a 70-kda cyclin k (cyck) that binds cdk12 and cdk13 to form two different complexes (cyck/cdk12 or cyck/cdk13) in human cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK12 | form complex
binding
|
CyclinK/CDK12 |
0.941 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176789 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
We identified a 70-kda cyclin k (cyck) that binds cdk12 and cdk13 to form two different complexes (cyck/cdk12 or cyck/cdk13) in human cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CyclinK/CDK12
CPX-241