Summary

Name CDK12
Full Name Cyclin-dependent kinase 12
Synonyms Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12, hCDK12 | CRK7, CRKRS, KIAA0904
Primary ID Q9NYV4
Links - -
Type protein
Relations 18
Function Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation POLR2A 0.773
Publications: 12 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation POLR2A 0.773
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAK2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDK12 0.483
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation CDK12 0.515
Publications: 1
+ form complex img/form-complex.png binding CyclinK/CDK12 0.94
Publications: 1 Organism: Homo Sapiens