Relation Results

Name	IL37
Full Name	Interleukin-37
Synonyms	IL-37, FIL1 zeta, IL-1X, Interleukin-1 family member 7, IL-1F7, Interleukin-1 homolog 4, IL-1H, IL-1H4, Interleukin-1 zeta, IL-1 zeta, Interleukin-1-related protein, IL-1RP1 \| FIL1Z, IL1F7, IL1H4, IL1RP1
Primary ID	Q9NZH6
Links	- -
Type	protein
Relations	1
Function	Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269\|PubMed:18390730, ECO:0000269\|PubMed:20935647, ECO:0000269\|PubMed:33674380}.