Summary

Name CNOT2
Full Name CCR4-NOT transcription complex subunit 2
Synonyms CCR4-associated factor 2 | CDC36, NOT2
Primary ID Q9NZN8
Links - -
Type protein
Relations 1
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.

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Relations

Regulator Mechanism target score ℹ
+ CNOT2form complex img/form-complex.png binding CCR4-NOT complex 0.823
Publications: 1 Organism: Homo Sapiens