| + |
LRP1B | down-regulates 
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259091 |
|
|
Homo sapiens |
SW-480 Cell, SW-620 Cell |
| pmid |
sentence |
| 28408316 |
Forced expression of LRP1B in SW480 and SW620 cells inhibited the growth, migration and anchorage-independent growth of cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259089 |
|
|
Homo sapiens |
Calu-1 Cell |
| pmid |
sentence |
| 27626682 |
Conversely, in Calu-1 cells, which express higher endogenous levels of the receptor, siRNA-mediated LRP1B knockdown significantly enhanced cellular proliferation. Taken together, these findings demonstrate that, consistent with the postulated tumor suppressor function, overexpression of full-length Lrp1b leads to impaired cellular proliferation, while LRP1B knockdown has the opposite effect. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
LRP1B | down-regulates activity 
binding
|
DVL2 |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28408316 |
In this study, we have shown that LRP1B inhibited the activity of beta-catenin/TCF signaling possibly by interacting with DVL2. The molecular mechanism study revealed that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LRP1B
- 
- 