3.0
Summary
| Name |  TBC1D7View Modifications |
| Full Name | TBC1 domain family member 7 |
| Synonyms | Cell migration-inducing protein 23 | TBC7 |
| Primary ID | Q9P0N9 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question. |
phosphorylation