3.0
Summary
| Name |  CALCOCO1
|
| Full Name | Calcium-binding and coiled-coil domain-containing protein 1 |
| Synonyms | Calphoglin, Coiled-coil coactivator protein, Sarcoma antigen NY-SAR-3 | KIAA1536 |
| Primary ID | Q9P1Z2 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). |
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transcriptional regulation
ubiquitination