4.0
Summary
| Name |  HEY2
|
| Full Name | Hairy/enhancer-of-split related with YRPW motif protein 2 |
| Synonyms | Cardiovascular helix-loop-helix factor 1, hCHF1, Class B basic helix-loop-helix protein 32, bHLHb32, HES-related repressor protein 2, Hairy and enhancer of split-related protein 2, HESR-2, Hairy-related transcription factor 2, HRT-2, hHRT2, Protein gridlock homolog | BHLHB32, CHF1, GRL, HERP, HERP1, HRT2 |
| Primary ID | Q9UBP5 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NOTCH | up-regulates quantity by expression 
transcriptional regulation
|
HEY2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NOTCH4 | up-regulates quantity by expression
transcriptional regulation
|
HEY2 | 0.616 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HEY2 | down-regulates 
binding
|
NOTCH1 | 0.768 |
| Publications: | 1 | Organism: | Homo Sapiens | |