| + |
PSEN1 | up-regulates 
cleavage
|
NOTCH |
0.796 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10593990 |
Presenilin-1 (ps1), a polytopic membrane protein primarily localized to the endoplasmic reticulum, is required for efficient proteolysis of both notch and beta-amyloid precursor protein (app) within their trans- membrane domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK8 | down-regulates 
phosphorylation
|
NOTCH |
0.551 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254312 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15546612 |
Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG2 | up-regulates
binding
|
NOTCH |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269935 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10958687 |
Binding of delta1, jagged1, and jagged2 to notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of notch2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression 
transcriptional regulation
|
JAG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254348 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20953350 |
Contact with skip is required for biological activity of notchic. A mutation in the fourth ankyrin repeat that abolished notch signal transduction did not affect interaction with cbf1 but abolished interaction with skip. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADAM10 | up-regulates activity
cleavage
|
NOTCH |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259836 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28624438 |
One of the most important and best characterized ADAM10 substrates is the Notch receptor [16]. After ligand binding to the Notch receptor, ADAM10 liberates the ectodomain and the membrane remaining part is processed by the γ-secretase complex, which releases a Notch Intracellular Domain (NICD). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNTN6 | up-regulates
relocalization
|
NOTCH |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254318 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15082708 |
Here, we establish that nb-3, a member of the f3/contactin family, acts as a novel notch ligand to participate in oligodendrocyte generation. Nb-3 triggers nuclear translocation of the notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via deltex1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
gamma-secretase | up-regulates activity
cleavage
|
NOTCH |
0.676 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254328 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25610395 |
The membrane-bound Notch segment that results from this cleavage, known as Notch Intracellular Truncation domain (NEXT), is a -secretase substrate (Kopan and Ilagan, 2009). -Secretase performs the subsequent cleavage at S3 (De Strooper et al., 1999), releasing Notch intracellular domain (NICD) from the membrane and allowing for signal transduction through binding with the CBL-1, Su(H), Lag-1 (CSL; Schroeter et al., 1998; Struhl and Adachi, 1998) family of DNA binding proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
|
PAX7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254343 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22493066 |
We provide evidence that notch and deltex may act on e47 by inhibiting signaling through ras because (i) full e47 activity was found to be dependent on ras and (ii) both notch and deltex inhibited gal4-jun, a hybrid transcription factor whose activity is dependent on signaling from ras to sapk/jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle, Satellite Cell |
| Pathways: | Acute Myeloid Leukemia |
| + |
KPNA3 | up-regulates
relocalization
|
NOTCH |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254321 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20454918 |
Nicd binds via one of its four potential nuclear localization signals to importins alfa3, alfa4, and alfa7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFL7 | down-regulates activity
binding
|
NOTCH |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266860 |
|
|
Mus musculus |
Neural Stem Cell |
| pmid |
sentence |
| 19503073 |
Here we have identified transmembrane receptors of the Notch family as EGFL7-binding molecules. Secreted EGFL7 binds to a region in Notch involved in ligand-mediated receptor activation, thus acting as an antagonist of Notch signalling. Expression of EGFL7 in neural stem cells (NSCs) in vitro decreased Notch-specific signalling and consequently, reduced proliferation and self-renewal of NSCs. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
XXYLT1 | up-regulates
binding
|
NOTCH |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254333 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22117070 |
Xxylt1 acts on the xyl1,3glc-o-linked glycan of notch egf domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML2 | up-regulates quantity by expression
transcriptional regulation
|
NOTCH |
0.863 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
We recently cloned a mammalian homologue of the mastermind gene of drosophila melanogaster, maml1 (mastermind-like-1 molecule) and determined that it functions as a transcriptional coactivator for notch receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLL1 | up-regulates
binding
|
NOTCH |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255368 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
When activated by its ligands (Delta and Jagged in vertebrates and Serrate in invertebrates), the intracellular portion of Notch is cleaved and translocates to the nucleus |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255369 |
|
|
|
|
| pmid |
sentence |
| 23729744 |
The NECD undergoes O-linked glycosylation during Notch synthesis and secretion, which is crucial for proper folding of the Notch receptor and the interaction with its ligand DSL (Delta, Serrate, Lag-2)(Rana and Haltiwanger, 2011). The Notch receptor on the signal-receiving cell binds directly to ligands located on the apposing signal-sending cell |
|
| Publications: |
2 |
| Tissue: |
Skeletal Muscle |
| + |
SMAD3 | up-regulates
binding
|
NOTCH |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254325 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14638857 |
Nicd and smad3 were shown to interact directly, both in vitro and in cells, in a ligand-dependent manner, and smad3 could be recruited to csl-binding sites on dna in the presence of csl and nicd |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | down-regulates
phosphorylation
|
NOTCH |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254313 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19383720 |
Dyrk1a physically interacts with the nicd inducing its phosphorylation in the ankyrin domain, thereby attenuating notch . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
KAT2B | up-regulates
acetylation
|
NOTCH |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254311 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22120716 |
In earlier studies, we demonstrated that maml1 enhanced p300 acetyltransferase activity, which increased the acetylation of notch by p300.Acetylation controls notch stability and function in t-cell leukemia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | form complex 
binding
|
RBPJ/NOTCH |
0.951 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255364 |
|
|
|
|
| pmid |
sentence |
| 22045613 |
NICD is translocated to the nucleus where it binds recombining binding protein-Jj (RBP-Jj) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255363 |
|
|
|
|
| pmid |
sentence |
| 7566092 |
Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-Jk and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255377 |
|
|
|
|
| pmid |
sentence |
| 23729744 |
The released NICD translocates directly to the nucleus, where it forms a transcriptional complex with the DNA-binding protein CSL (CBF1, Suppressor of Hairless, Lag1), Mastermind (Mam) and transcriptional co-activators to drive the expression of Notch target genes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255380 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
Notch is cleaved and translocates to the nucleus, where it activates a family of transcription factors, exemplified by Suppressor of Hairless and CBF/RJBk |
|
| Publications: |
4 |
| Tissue: |
Skeletal Muscle |
| + |
SDC3 | up-regulates activity
binding
|
NOTCH |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254329 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 20696709 |
Furthermore, we show that Syndecan-3 interacts with Notch and is required for Notch processing by ADAM17/tumor necrosis factor-€“converting enzyme (TACE) and signal transduction. Together, our data support the conclusion that Syndecan-3 and Notch cooperate in regulating homeostasis of the satellite cell population and myofiber size. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CKM complex | down-regulates quantity by destabilization
phosphorylation
|
NOTCH |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273153 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15546612 |
Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HEY1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254341 |
|
|
Mus musculus |
C2C12 Cell, Osteoblast |
| pmid |
sentence |
| 15207708 |
Deltex, meltrin beta, ifi-202, and ifi-204 were also upregulated by notchic in the 2b4.11 t cell hybridoma, whereas ifi-d3 was expressed constitutively at relatively high levels and slightly upregulated by notchic, and pre-talfa was not expressed. Deltex, meltrin beta, pre-talfa, ifi-202, and ifi-204 were upregulated by notchic expression in the akr1 dp thymoma cell line, whereas ifi-d3 was not expressed |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO | down-regulates quantity 
transcriptional regulation
|
NOTCH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254306 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
FOXO3 | down-regulates quantity
transcriptional regulation
|
NOTCH |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254320 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DLL1 | up-regulates activity
binding
|
NOTCH |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254315 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 16140393 |
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
BCL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254344 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 16990763 |
Addition of jag-1 peptide induced ikkalpha mediated nf-kappab activation, as well as increased ppargamma expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
HIF1AN | down-regulates
hydroxylation
|
NOTCH |
0.552 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254324 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18299578 |
We show that fih-1 hydroxylates notch icd at two residues (n(1945) and n(2012)) that are critical for the function of notch icd as a transactivator within cells and during neurogenesis and myogenesis in vivo. Fih-1 negatively regulates notch activity and accelerates myogenic differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates
binding
|
MAML2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254347 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12386158 |
Other than a role in t-cell development, the hox genes may be involved in alternative notchregulated processes in hematopoietic stem cells. Notch signaling is clearly important for self-renewal of hematopoietic progenitors (reviewed by radkte et al. 57). Interestingly, hoxa5, a9 and a10 were found to be part of the stem cell profile' |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCNC | down-regulates
phosphorylation
|
NOTCH |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254309 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15546612 |
Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBPJ | down-regulates quantity by repression
transcriptional regulation
|
NOTCH |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255373 |
|
|
|
|
| pmid |
sentence |
| 23729744 |
In the absence of NICD, CSL forms complexes with a variety of co-repressors to suppress the transcription of Notch target genes |
|
| Publications: |
1 |
| + |
EIF3F | up-regulates
deubiquitination
|
NOTCH |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254327 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21124883 |
The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates
|
BMPR1A/1B/2 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254335 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Similar synergy is found in notch and bmp crosstalk: activating notch signaling enhanced bmp-induced alp activity and formation of calcified nodules in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML1 | up-regulates
binding
|
NOTCH |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11101851 |
Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HEYL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254339 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11044625 |
The intracellular part of the notch receptor is cleaved off and translocates to the nucleus, where it binds to the transcription factor rbp-j. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
NUMB | down-regulates
|
NOTCH |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255374 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
Numb is an inhibitor of Notch signaling that interacts with the intracellular portion of Notch and antagonizes its activity by preventing nuclear translocation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255375 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
Therefore, these genetic data further support the hypothesis that activation of Notch-1 promotes a less committed myogenic phenotype and that the attenuation of Notch-1 activity by Numb promotes progression along the myogenic lineage toward a myoblast cell fate. |
|
| Publications: |
2 |
| Tissue: |
Skeletal Muscle |
| + |
KPNA6 | up-regulates
relocalization
|
NOTCH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254332 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20454918 |
Nicd binds via one of its four potential nuclear localization signals to importins alfa3, alfa4, and alfa7. importins alpha3, alpha4 (and to a lesser extent, alpha7) mediate nuclear import of nicd and thus are directly involved in notch signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11486031 |
Moreover, as determined by using coimmunoprecipitation assays, each maml protein was found to be capable of forming a multiprotein complex with the intracellular domain of each notch receptor (icn1 to -4) and csl in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
DTX1 | up-regulates activity
ubiquitination
|
NOTCH |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254317 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 22162134 |
The expression of dx, which physically interacts with notch, favors a mono-ubiquitinated state of the receptor, which leads to a ligand-independent intracellular activation of notch |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
POFUT1 | up-regulates
binding
|
NOTCH |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254326 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12909620 |
Notch_ is modified in its epidermal growth factor-like domains by the addition of_ fucose_ to serine or threonine residues. O-fucosylation is mediated by protein o-fucosyltransferase 1 and down-regulation of this enzyme by rna interference or mutation of the ofut1 gene in drosophila or by mutation of the pofut1 gene in mouse prevents notch signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KPNA4 | up-regulates
relocalization
|
NOTCH |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254322 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20454918 |
Nicd binds via one of its four potential nuclear localization signals to importins alfa3, alfa4, and alfa7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG1 | up-regulates
binding
|
NOTCH |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10551863 |
Here we report the first x-ray structure of a functional fragment of a notch ligand, the dsl-egf3 domains of human jagged-1 (j-1dsl-egf3). The structure identifies a highly conserved face of the dsl domain and we show, by functional analysis of drosophila ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with notch. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261534 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32195003 |
Notch signaling is initiated by the interaction of Notch ligands and receptors on adjacent cells, which further triggers two proteolytic cleavage events. The first cleavage releases a functional extracellular domain (NECD); the second cleavage, mediated by γ-secretase, releases the intracellular domain (NICD) into the cytoplasm. The NICD then translocates to the nucleus, binds to the transcription factor CBF/Su (H)/LAG-2 (CSL), and recruits Mastermind-like protein 1 and p300/CBP to induce transcription of Notch target genes, including Hes1, p21, Akt, cyclin D1, and mTOR |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
NOTCH | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255376 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
Taken together, these results show that Notch-1 activity promotes myogenic cell proliferation and that attenuation of Notch-1 activity by its antagonist Numb causes cells to exit from the cell cycle, express MRFs, and undergo myogenic differentiation. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HEY2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254338 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12548545 |
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GXYLT2 | up-regulates
binding
|
NOTCH |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254314 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22117070 |
Recently, we have shown (28) that two members of the human glycosyltransferase 8 family (gt8) (29), gxylt1 and gxylt2 (glucoside-xylosyltransferase 1/2), are able to transfer the first alfa1,3-linked xylose to o-glucosylated mammalian notch egf repeats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | down-regulates activity
binding
|
NOTCH |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254305 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 12913000 |
Taken together, these results indicate that transcription factor YY1 may modulate Notch signaling via association with the high molecular weight Notch complex [..] both YY1 and N1IC were present in a large complex of the nucleus to suppress the luciferase reporter activity transactivated by Notch signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML3 | up-regulates
binding
|
NOTCH |
0.884 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
We report here the cloning and characterization of two new genes, maml2 and maml3, that also function as transcriptional coactivators for notch receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITCH | down-regulates
ubiquitination
|
NOTCH |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254331 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10940313 |
Itch binds to the n-terminal portion of the notch intracellular domain via its ww domains and promotes ubiquitination of notch through its hect ubiquitin ligase domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
NOTCH | up-regulates
binding
|
MAML3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254346 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
Genetic ablation or activation of the pathway reveals that Notch signalling promotes differentiation of the hair follicle, sebaceous gland and interfollicular epidermal lineages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADAM17 | up-regulates
cleavage
|
NOTCH |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255371 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23729744 |
Receptor–ligand engagement triggers a second NECD cleavage (S2 cleavage) by a metalloproteinase ADAM (known as Kuzbanian in Drosophila melanogaster) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255370 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18344021 |
Two ADAMs have been implicated in the S2 cleavage of Notch. In Drosophila, ADAM10 ortholog Kuzbanian is the main protease mediating Notch processing [35–38]. In mouse cells in vitro, ADAM17, and not ADAM10, appears to be a protease responsible for Notch cleavage |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
POGLUT1 | up-regulates
glycosylation
|
NOTCH |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254319 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22872643 |
O-glucosylation of epidermal growth factor-like (egf) repeats in the extracellular domain of notch is essential for notch function. A udp-glucose:protein o-glucosyltransferase (poglut/rumi) transfers o-glucose to serine within the o-glucose consensus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates
binding
|
SNW1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254337 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10713164 |
Notch signal transduction pathway genes, lfng, hey1, and hes1, are differen-tially regulated by bmp-2 and tgf-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
IL7R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254345 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22577461 |
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
gamma-secretase | up-regulates
cleavage
|
NOTCH |
0.676 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255372 |
|
|
|
|
| pmid |
sentence |
| 23729744 |
Receptor–ligand engagement triggers a second NECD cleavage (S2 cleavage) by a metalloproteinase ADAM (known as Kuzbanian in Drosophila melanogaster), which in turn facilitates a further crucial signaling cleavage within the Notch transmembrane domain by a γ-secretase complex that contains Presenilin (S3 cleavage) |
|
| Publications: |
1 |
| + |
ADAM17 | up-regulates activity
cleavage
|
NOTCH |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254334 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10882063 |
... here we show that an additional processing event occurs in the extracellular part of the receptor, preceding cleavage by the gamma-secretase-like activity. Purification of the activity accounting for this cleavage in vitro shows that it is due to tace (tnfalpha-converting enzyme), a member of the adam (a disintegrin and metalloprotease domain) family of metalloproteases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
LFNG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Notch signal transduction pathway genes, lfng, hey1, and hes1, are differen-tially regulated by bmp-2 and tgf-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
ADAM19 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254340 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10933396 |
Interestingly, in absence of delta signal, both hes-1 and tcfl5 decreased, and further decreased by incubation with dapt. (figure 4). This pharmacological approach therefore provides additional evidence that tcfl5, similar to hes1, is a true notch target gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
PIN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254342 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19151708 |
Previously, we have shown that commitment of the C2C12 cells to the osteoblastic lineage occurs around 24h after BMP treatment, when the osteoblast specific transcription factor Cbfa1 and the novel osteoblast related genes Tcf7 and Hey1 become regulated |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIAH1 | up-regulates
relocalization
|
NOTCH |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20940030 |
The overexpression of siah1 causes the re-localization of notch from the cell surface to the cytoplasm and to the nucleus, which is indicative of notch activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLL3 | up-regulates activity
binding
|
NOTCH |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254316 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 16140393 |
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXW7 | down-regulates quantity by destabilization
ubiquitination
|
NOTCH |
0.614 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254310 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15546612 |
Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
3.0
NOTCH