| + |
ATR | down-regulates 
phosphorylation
|
DBF4 |
0.66 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177805 |
Ser502 |
FSTDNSGsQPKQKSD |
Homo sapiens |
|
| pmid |
sentence |
| 22123827 |
Dbf4/cdc7 (dbf4-dependent kinase (ddk)) is activated at the onset of s-phase, and its kinase activity is required for dna replication initiation from each origin. We identified novel atm/atr phosphorylation sites on dbf4 and showed that atm/atr-mediated phosphorylation of dbf4 is critical for the intra-s-phase checkpoint to inhibit dna replication. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177809 |
Ser539 |
GLITINSsQEHLTVQ |
Homo sapiens |
|
| pmid |
sentence |
| 22123827 |
Dbf4/cdc7 (dbf4-dependent kinase (ddk)) is activated at the onset of s-phase, and its kinase activity is required for dna replication initiation from each origin. We identified novel atm/atr phosphorylation sites on dbf4 and showed that atm/atr-mediated phosphorylation of dbf4 is critical for the intra-s-phase checkpoint to inhibit dna replication. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177813 |
Thr449 |
DDIRQNFtQLPLHKN |
Homo sapiens |
|
| pmid |
sentence |
| 22123827 |
Dbf4/cdc7 (dbf4-dependent kinase (ddk)) is activated at the onset of s-phase, and its kinase activity is required for dna replication initiation from each origin. We identified novel atm/atr phosphorylation sites on dbf4 and showed that atm/atr-mediated phosphorylation of dbf4 is critical for the intra-s-phase checkpoint to inhibit dna replication. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
ATM | down-regulates
phosphorylation
|
DBF4 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177793 |
Ser502 |
FSTDNSGsQPKQKSD |
Homo sapiens |
|
| pmid |
sentence |
| 22123827 |
Dbf4/cdc7 (dbf4-dependent kinase (ddk)) is activated at the onset of s-phase, and its kinase activity is required for dna replication initiation from each origin. We identified novel atm/atr phosphorylation sites on dbf4 and showed that atm/atr-mediated phosphorylation of dbf4 is critical for the intra-s-phase checkpoint to inhibit dna replication. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177797 |
Ser539 |
GLITINSsQEHLTVQ |
Homo sapiens |
|
| pmid |
sentence |
| 22123827 |
Dbf4/cdc7 (dbf4-dependent kinase (ddk)) is activated at the onset of s-phase, and its kinase activity is required for dna replication initiation from each origin. We identified novel atm/atr phosphorylation sites on dbf4 and showed that atm/atr-mediated phosphorylation of dbf4 is critical for the intra-s-phase checkpoint to inhibit dna replication. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177801 |
Thr449 |
DDIRQNFtQLPLHKN |
Homo sapiens |
|
| pmid |
sentence |
| 22123827 |
Dbf4/cdc7 (dbf4-dependent kinase (ddk)) is activated at the onset of s-phase, and its kinase activity is required for dna replication initiation from each origin. We identified novel atm/atr phosphorylation sites on dbf4 and showed that atm/atr-mediated phosphorylation of dbf4 is critical for the intra-s-phase checkpoint to inhibit dna replication. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
4.0
DBF4
- 
- 