Summary

Name NXF1
Full Name Nuclear RNA export factor 1
Synonyms Tip-associated protein, Tip-associating protein, mRNA export factor TAP | TAP
Primary ID Q9UBU9
Links - -
Type protein
Relations 6
Function Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs

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Relations

Regulator Mechanism target score ℹ
+ SRSF7up-regulates img/direct-activation.png binding NXF1 0.671
Publications: 1 Organism: Homo Sapiens
+ NXF1form complex img/form-complex.png binding RBM15/NXF1 0.489
Publications: 1 Organism: Homo Sapiens
+ LINC complexup-regulates activity img/direct-activation.png binding NXF1 0.302
Publications: 1 Organism: Homo Sapiens
+ NXF1up-regulates img/indirect-activation.png mRNA-nucleus_export 0.7
Publications: 1 Organism: Homo Sapiens
+ SRSF3up-regulates img/direct-activation.png binding NXF1 0.682
Publications: 1 Organism: Homo Sapiens
+ SUN1up-regulates activity img/direct-activation.png binding NXF1 0.355
Publications: 1 Organism: Homo Sapiens