3.0
Summary
| Name |  SRSF3
|
| Full Name | Serine/arginine-rich splicing factor 3 |
| Synonyms | Pre-mRNA-splicing factor SRP20, Splicing factor, arginine/serine-rich 3 | SFRS3, SRP20 |
| Primary ID | P84103 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1 |
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dephosphorylation
binding