Summary

Name TRIM10
Full Name Tripartite motif-containing protein 10
Synonyms B30-RING finger protein, RING finger protein 9 | RFB30, RNF9
Primary ID Q9UDY6
Links - -
Type protein
Relations 1
Function E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647).

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination TRIM10 0.2
Publications: 1 Organism: Homo Sapiens