Summary

Name CNOT8
Full Name CCR4-NOT transcription complex subunit 8
Synonyms CAF1-like protein, CALIFp, CAF2, CCR4-associated factor 8, Caf1b | CALIF, POP2
Primary ID Q9UFF9
Links - -
Type protein
Relations 1
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

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Relations

Regulator Mechanism target score ℹ
+ CNOT8form complex img/form-complex.png binding CCR4-NOT complex 0.784
Publications: 1 Organism: Homo Sapiens