Name	ZRANB1 View Modifications
Full Name	Ubiquitin thioesterase ZRANB1
Synonyms	EC 3.4.19.12, TRAF-binding domain-containing protein, hTrabid, Zinc finger Ran-binding domain-containing protein 1 \| TRABID
Primary ID	Q9UGI0
Links	- -
Type	protein
Relations	6
Function	Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Required in the stress fiber dynamics and cell migration (PubMed:21834987). {ECO:0000269\|PubMed:18281465, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:22157957, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:25752573, ECO:0000269\|PubMed:25752577, ECO:0000269\|PubMed:33637724}.