Summary

Name UVRAG
Full Name UV radiation resistance-associated gene protein
Synonyms p63
Primary ID Q9P2Y5
Links - -
Type protein
Relations 11
Pathways Autophagy
Function Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ SMURF1down-regulates activity img/direct_inhibition.png ubiquitination UVRAG 0.2
Publications: 2 Organism: Homo Sapiens
+ MTORup-regulates activity img/direct-activation.png phosphorylation UVRAG 0.419
Publications: 2 Organism: Homo Sapiens
+ UVRAGform complex img/form-complex.png binding Vps34 Complex II 0.815
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ UVRAGup-regulates activity img/direct-activation.png binding BECN1 0.857
Publications: 2 Organism: Homo Sapiens
Pathways:Autophagy
+ UVRAGup-regulates activity img/direct-activation.png binding RINT1 0.512
Publications: 1 Organism: Homo Sapiens
+ ZRANB1up-regulates activity img/direct-activation.png deubiquitination UVRAG 0.2
Publications: 1 Organism: Homo Sapiens
+ UVRAGup-regulates activity img/direct-activation.png binding PIK3C3 0.803
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ TFE3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UVRAG 0.267
Publications: 1