+ |
EGFL7 | up-regulates
|
Neurogenesis |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266859 |
|
|
Homo sapiens |
|
pmid |
sentence |
20372059 |
EGFL7 drives the formation of neurons from neural stem cells. In the embryonic and adult brain this process is essential for neurogenesis and homeostasis of the nervous system. In this review, we discuss the implications of our findings for adult neurogenesis and illustrate the potential of EGFL7 to serve as an agent to increase neurogenesis and the self-renewal potential of the brain |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EGFL7 | down-regulates activity
binding
|
NOTCH |
0.488 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266860 |
|
|
Mus musculus |
Neural Stem Cell |
pmid |
sentence |
19503073 |
Here we have identified transmembrane receptors of the Notch family as EGFL7-binding molecules. Secreted EGFL7 binds to a region in Notch involved in ligand-mediated receptor activation, thus acting as an antagonist of Notch signalling. Expression of EGFL7 in neural stem cells (NSCs) in vitro decreased Notch-specific signalling and consequently, reduced proliferation and self-renewal of NSCs. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
CASZ1 | up-regulates quantity
transcriptional regulation
|
EGFL7 |
0.438 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266858 |
|
|
Homo sapiens |
Endothelial Cell |
pmid |
sentence |
24150064 |
We have recently demonstrated that a novel transcriptional pathway involving activation of the Epidermal Growth Factor-like Domain 7 (Egfl7) gene by the transcription factor CASTOR (CASZ1) is required for blood vessel assembly and lumen morphogenesis. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |