Relation Results

Summary

Name MAD2L2
Full Name Mitotic spindle assembly checkpoint protein MAD2B
Synonyms Mitotic arrest deficient 2-like protein 2, MAD2-like protein 2, REV7 homolog, hREV7 | MAD2B, REV7
Primary ID Q9UI95
Links - -
Type protein
Relations 4
Function Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:1771 ...
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Type: Score: Layout: SPV 
0.5290.5090.470.51MAD2L2FZR1PRCCCDC20CHAMP1

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Relations
Regulator
Mechanism
target
score ℹ
+ MAD2L2down-regulates activity img/direct_inhibition.png binding FZR1 0.529
Identifier Residue Sequence Organism Cell Line
SIGNOR-264902 in vitro
pmid sentence
The APC is activated in mitosis and G1 by CDC20 and CDH1, and inhibited by the checkpoint protein MAD2, a specific inhibitor of CDC20. We show here that a MAD2 homolog MAD2B also inhibits APC. MAD2B directly inhibits activation of APC by CDC20 and CDH1
Publications: 1 Organism: In Vitro
+ PRCCup-regulates img/direct-activation.png relocalization MAD2L2 0.509
Identifier Residue Sequence Organism Cell Line
SIGNOR-126516 Homo sapiens
pmid sentence
We found that the human papillary renal cell carcinoma-associated proteinprccinteracts with the cell cycle control proteinmad2b, and translocates this protein to the nucleus where it exerts its mitotic checkpoint function.
Publications: 1 Organism: Homo Sapiens
+ MAD2L2down-regulates activity img/direct_inhibition.png binding CDC20 0.47
Identifier Residue Sequence Organism Cell Line
SIGNOR-264903 in vitro
pmid sentence
The APC is activated in mitosis and G1 by CDC20 and CDH1, and inhibited by the checkpoint protein MAD2, a specific inhibitor of CDC20. We show here that a MAD2 homolog MAD2B also inhibits APC. MAD2B directly inhibits activation of APC by CDC20 and CDH1
Publications: 1 Organism: In Vitro
+ CHAMP1up-regulates activity img/direct-activation.png binding MAD2L2 0.51
Identifier Residue Sequence Organism Cell Line
SIGNOR-264904 Homo sapiens
pmid sentence
Here, we report a novel regulator for accurate chromosome segregation, chromosome alignment-maintaining phosphoprotein (CAMP). We identified CAMP as a MAD2L2-interacting protein. Spindle localization of MAD2L2 was abrogated by CAMP depletion (Supplementary Figure S2A)
Publications: 1 Organism: Homo Sapiens
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