Summary

Name CNOT7
Full Name CCR4-NOT transcription complex subunit 7
Synonyms BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a | CAF1
Primary ID Q9UIV1
Links - -
Type protein
Relations 1
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ CNOT7form complex img/form-complex.png binding CCR4-NOT complex 0.83
Publications: 1 Organism: Homo Sapiens