Summary

Name MAGEL2
Full Name MAGE-like protein 2
Synonyms Necdin-like protein 1, Protein nM15 | NDNL1
Primary ID Q9UJ55
Links - -
Type protein
Relations 4
Function Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ MAGEL2up-regulates activity img/direct-activation.png binding TRIM27 0.536
Publications: 1 Organism: Homo Sapiens
+ ARNTLdown-regulates activity img/direct_inhibition.png binding MAGEL2 0.378
Publications: 1 Organism: Homo Sapiens
+ CLOCKdown-regulates activity img/direct_inhibition.png binding MAGEL2 0.2
Publications: 1 Organism: Homo Sapiens
+ MAGEL2up-regulates activity img/direct-activation.png binding WASHC1 0.2
Publications: 1 Organism: Homo Sapiens