| + |
TRIM27 | up-regulates activity 
ubiquitination
|
STK38L |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270347 |
Lys119 |
TGHIYAMkILRKSDM |
Mus musculus |
|
| pmid |
sentence |
| 35670107 |
TRIM27 catalyzes non-degradative K6- and K11-linked ubiquitination of the serine/threonine kinase 38-like (STK38L) kinase. In turn, STK38L ubiquitination promotes its activation and phosphorylation of ULK1 at Ser495, rendering ULK1 in a permissive state for TRIM27-mediated hyper-ubiquitination of ULK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270346 |
Lys73 |
RRSQHARkETEFLRL |
Mus musculus |
|
| pmid |
sentence |
| 35670107 |
TRIM27 catalyzes non-degradative K6- and K11-linked ubiquitination of the serine/threonine kinase 38-like (STK38L) kinase. In turn, STK38L ubiquitination promotes its activation and phosphorylation of ULK1 at Ser495, rendering ULK1 in a permissive state for TRIM27-mediated hyper-ubiquitination of ULK1 |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
TRIM27 | up-regulates activity
ubiquitination
|
WASHC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253514 |
Lys220 |
DAPLSISkREQLEQQ |
Homo sapiens |
|
| pmid |
sentence |
| 23452853 |
Our mechanistic studies uncovered that K63-linked ubiquitination of WASH K220 by MAGE-L2-TRIM27 is required for endosomal F-actin nucleation and retrograde transport. These results suggest that K63-linked ubiquitination of WASH K220 by TRIM27 is required for WASH function in retrograde transport. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | down-regulates quantity by destabilization 
ubiquitination
|
ULK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272540 |
Lys569 |
DLHVVRPkLPKPPTD |
Mus musculus |
|
| pmid |
sentence |
| 35670107 |
TRIM27 directly polyubiquitinates ULK1 at K568 and K571 sites with K48-linked ubiquitin chains, with proteasomal turnover maintaining control over basal ULK1 levels |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272541 |
Lys572 |
VVRPKLPkPPTDPLG |
Mus musculus |
|
| pmid |
sentence |
| 35670107 |
TRIM27 directly polyubiquitinates ULK1 at K568 and K571 sites with K48-linked ubiquitin chains, with proteasomal turnover maintaining control over basal ULK1 levels |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
TRIM27 | up-regulates 
|
MAPK13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
Here we show that ectopic expression of rfp in human embryonic kidney 293 cells causes extensive apoptosis, as assessed by multiple criteria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
TRIM27 | up-regulates
|
MAPK14 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
TRIM27 | up-regulates
|
MAPK11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102022 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
TRIM27 | up-regulates
|
MAPK8 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102034 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
Rfp expression in hek 293 cells activated jnk1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
TRIM27 | up-regulates
|
p38 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
TRIM27 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271073 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | down-regulates
ubiquitination
|
PIK3C2B |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177935 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22128329 |
We now show that trim27 functions as an e3 ligase and mediates lysine 48 polyubiquitination of pi3kc2_, leading to a decrease in pi3k enzyme activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
Here we show that ectopic expression of rfp in human embryonic kidney 293 cells causes extensive apoptosis, as assessed by multiple criteria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
TRIM27 | down-regulates quantity
ubiquitination
|
ULK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270349 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 35670107 |
STK38L ubiquitination promotes its activation and phosphorylation of ULK1 at Ser495, rendering ULK1 in a permissive state for TRIM27-mediated hyper-ubiquitination |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAGEL2 | up-regulates activity
binding
|
TRIM27 |
0.542 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253513 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23452853 |
MAGE proteins are a family of proteins that contain a conserved domain known as the MAGE homology domain. Recently, we showed that MAGE proteins function biochemically to bind to and enhance the activity of E3 RING ubiquitin ligases. The E3 RING ubiquitin ligase TRIM27 was identified as a major binding partner of MAGE-L2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | up-regulates
|
MAPK12 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102025 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
3.0
TRIM27
- 
- 