| + |
phosphatidylglycerol(1-) | up-regulates activity 
chemical activation
|
CRLS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267029 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16678169 |
The mitochondrial phospholipid cardiolipin is synthesized from cytidinediphosphate-diacylglycerol and phosphatidylglycerol, a process catalyzed by the enzyme cardiolipin synthase. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PINK1 | down-regulates quantity 
phosphorylation
|
CRLS1 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280065 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24703837 |
In vitro kinase assays using recombinant proteins under various control conditions indicated that PINK1 directly phosphorylates CLS1 (XREF_FIG).|Similar to Fbxo15, knockdown of PINK1 kinase using shRNA increased CLS1 levels, whereas overexpression of PINK1 plasmid decreased CLS1 levels . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRLS1 | up-regulates
chemical modification
|
cardiolipin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267028 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16678169 |
The mitochondrial phospholipid cardiolipin is synthesized from cytidinediphosphate-diacylglycerol and phosphatidylglycerol, a process catalyzed by the enzyme cardiolipin synthase. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXO15 | down-regulates quantity by destabilization
binding
|
CRLS1 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272170 |
|
|
Homo sapiens |
A549-CR Cell |
| pmid |
sentence |
| 24703837 |
Fbxo15 Targets CLS1 Protein for Ubiquitination and Degradation to Disrupt Mitochondrial Function. S. aureus infection induces expression of a kinase, PINK1, that phosphorylates an indispensable protein CLS1, which in turn triggers CLS1 ubiquitination and degradation by the F box protein (SCFFbxo15). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CRLS1
- 
- 