+ |
HOOK1 | down-regulates activity
binding
|
PTPN11 |
0.362 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260642 |
|
|
Homo sapiens |
A-549 Cell |
pmid |
sentence |
25331952 |
The protein-tyrosine phosphatase domain and N-terminal SH2 domain of SHP2 directly interacted with Hook1. Down-regulation of Hook1 increased SHP2 activity. These results suggested that Hook1 was an endogenous negative regulator of SHP2 phosphatase activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
HOOK1 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260643 |
|
|
Homo sapiens |
A-549 Cell |
pmid |
sentence |
25331952 |
The epithelial-mesenchymal transition (EMT) is an essential process for embryogenesis. It also plays a critical role in the initiation of tumor metastasis.Overexpression of Hook1 inhibited EMT while knockdown of Hook1 promoted EMT. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |