+ |
BTK | up-regulates activity
phosphorylation
|
DDX41 |
0.415 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266404 |
Tyr414 |
DVIQEVEyVKEEAKM |
Mus musculus |
MEF Cell |
pmid |
sentence |
25704810 |
The kinase and SH3/SH2 interaction domains of BTK bind, respectively, the DEAD-box domain of DDX41 and transmembrane region of STING. BTK phosphorylates DDX41, and its kinase activities are critical for STING-mediated IFN-β production. We show that Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK phosphorylation site. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
DDX41 | up-regulates activity
binding
|
STING1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266403 |
|
|
Mus musculus |
MEF Cell |
pmid |
sentence |
25704810 |
The kinase and SH3/SH2 interaction domains of BTK bind, respectively, the DEAD-box domain of DDX41 and transmembrane region of STING. BTK phosphorylates DDX41, and its kinase activities are critical for STING-mediated IFN-β production. We show that Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK phosphorylation site. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
TRIM21 | down-regulates quantity
ubiquitination
|
DDX41 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278790 |
|
|
Homo sapiens |
|
pmid |
sentence |
23222971 |
Furthermore, overexpression of TRIM21 in mDCs led to lower expression of DDX41 in these mDCs and up to 70% less IFN-beta production by mDCs in response to intracellular DNA (XREF_FIG).|Here we report that the E3 ligase TRIM21 negatively regulated the type I interferon response in myeloid dendritic cells (mDCs) and monocytes that had been induced by cytosolic double stranded DNA (dsDNA), mainly by promoting the ubiquitination and degradation of DDX41. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |