Relation Results

Summary

Name USP21
Full Name Ubiquitin carboxyl-terminal hydrolase 21
Synonyms EC 3.4.19.12, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21 | USP23
Primary ID Q9UK80
Links - -
Type protein
Relations 2
Function Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitinati ...
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Type: Score: Layout: SPV 
0.2550.2MAPK14USP21STING1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPK14up-regulates activity img/direct-activation.png phosphorylation USP21 0.255
Identifier Residue Sequence Organism Cell Line
SIGNOR-273670 Ser538 VYNDSRVsPVSENQV Homo sapiens HeLa Cell
pmid sentence
In this study, we found that USP21 is an important deubiquitinating enzyme for STING and that it negatively regulates the DNA virus-induced production of type I interferons by hydrolyzing K27/63-linked polyubiquitin chain on STING. HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation of USP21 at Ser538. I
Publications: 1 Organism: Homo Sapiens
+ USP21down-regulates activity img/direct_inhibition.png deubiquitination STING1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273671 Homo sapiens HeLa Cell
pmid sentence
In this study, we found that USP21 is an important deubiquitinating enzyme for STING and that it negatively regulates the DNA virus-induced production of type I interferons by hydrolyzing K27/63-linked polyubiquitin chain on STING. HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation of USP21 at Ser538. I
Publications: 1 Organism: Homo Sapiens
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