Relation Results

Summary

Name RCOR1
Full Name REST corepressor 1
Synonyms Protein CoREST | KIAA0071, RCOR
Primary ID Q9UKL0
Links - -
Type protein
Relations 6
Function Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC com ...
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Type: Score: Layout: SPV 
0.7530.7590.9550.8230.7590.273RCOR1CoREST-HDAC complexRESTKDM1ABHC complexREST-CoRESTSCN2A

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Relations
Regulator
Mechanism
target
score ℹ
+ RCOR1form complex img/form-complex.png binding CoREST-HDAC complex 0.753
Identifier Residue Sequence Organism Cell Line
SIGNOR-222115 Homo sapiens HeLa Cell
pmid sentence
Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST Is a Component of an HDAC1/2 Complex. p40 is a Sox-like protein, p110b contains homology to polyamine oxidases, p110a is ZNF217, an eight-zinc finger protein, and p80 is a hypothetical protein of unknown function.
Publications: 1 Organism: Homo Sapiens
+ RCOR1up-regulates activity img/direct-activation.png binding REST 0.759
Identifier Residue Sequence Organism Cell Line
SIGNOR-220618 Homo sapiens HEK-293 Cell
pmid sentence
We show here that CoREST, a newly identified human protein, functions as a corepressor for REST. A single zinc finger motif in REST is required for CoREST interaction. Together, REST and CoREST mediate repression of the type II sodium channel promoter in nonneural cells, and the REST/CoREST complex may mediate long-term repression essential to maintenance of cell identity.
Publications: 1 Organism: Homo Sapiens
+ RCOR1up-regulates activity img/direct-activation.png binding KDM1A 0.955
Identifier Residue Sequence Organism Cell Line
SIGNOR-264506 in vitro
pmid sentence
CoREST protects LSD1 from proteasomal degradation and also plays an indispensable role in LSD1-mediated demethylation of nucleosomal substrates in vitro. in contrast to CoREST, which is a positive regulator of LSD1 activity, the in vitro evidence presented above suggests that BHC80 may function to inhibit LSD1 activity.
Publications: 1 Organism: In Vitro
+ RCOR1form complex img/form-complex.png binding BHC complex 0.823
Identifier Residue Sequence Organism Cell Line
SIGNOR-264498 Homo sapiens HeLa Cell, HEK-293 Cell
pmid sentence
BRAF–HDAC complex (BHC) consisting of six subunit proteins, BRAF35, BHC80, BHC110, HDAC1, HDAC2, and CoREST, has been purified from HeLa and HEK293 cells
Publications: 1 Organism: Homo Sapiens
+ RCOR1form complex img/form-complex.png binding REST-CoREST 0.759
Identifier Residue Sequence Organism Cell Line
SIGNOR-239220 Homo sapiens
pmid sentence
Transcriptional repression of neural-specific genes in nonneuronal cells is dependent on the REST (RE1-silencing transcription factor)–CoREST complex.
Publications: 1 Organism: Homo Sapiens
+ RCOR1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN2A 0.273
Identifier Residue Sequence Organism Cell Line
SIGNOR-220695 Homo sapiens HEK-293 Cell
pmid sentence
We show here that CoREST, a newly identified human protein, functions as a corepressor for REST. A single zinc finger motif in REST is required for CoREST interaction. Together, REST and CoREST mediate repression of the type II sodium channel promoter in nonneural cells, and the REST/CoREST complex may mediate long-term repression essential to maintenance of cell identity.
Publications: 1 Organism: Homo Sapiens
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