| + |
CoREST-HDAC complex | up-regulates 
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32101746 |
The CoREST complex is one of seven families of class I histone deacetylase complexes that have specialized physiological functions but are all thought to act as repressors of gene expression. CoREST is unique within these complexes in that it removes both acetyl and methyl modifications through the activity of its demethylase (LSD1) and deacetylase (HDAC1) enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RCOR1 | form complex 
binding
|
CoREST-HDAC complex |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222115 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11171972 |
Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST Is a Component of an HDAC1/2 Complex. p40 is a Sox-like protein, p110b contains homology to polyamine oxidases, p110a is ZNF217, an eight-zinc finger protein, and p80 is a hypothetical protein of unknown function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNF217 | form complex
binding
|
CoREST-HDAC complex |
0.552 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222118 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11171972 |
Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST Is a Component of an HDAC1/2 Complex. p40 is a Sox-like protein, p110b contains homology to polyamine oxidases, p110a is ZNF217, an eight-zinc finger protein, and p80 is a hypothetical protein of unknown function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CoREST-HDAC complex | down-regulates quantity by repression 
transcriptional regulation
|
SCN2A |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268541 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16140033 |
This suggests that the HDACs in the LSD1 complex are likely to function upstream of CoREST/LSD1, generating a hypoacetylated histone substrate, which can then be better recognized by CoREST/LSD1. Further supporting this model, we found that inhibition of HDAC activity by TSA resulted in derepression of two LSD1 target genes, the human neuronal-specific sodium channel (SCN) genes, SCNA2 and SCNA3 (Figure 1H). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC2 | form complex
binding
|
CoREST-HDAC complex |
0.692 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222127 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11171972 |
Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST Is a Component of an HDAC1/2 Complex. p40 is a Sox-like protein, p110b contains homology to polyamine oxidases, p110a is ZNF217, an eight-zinc finger protein, and p80 is a hypothetical protein of unknown function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM1A | form complex
binding
|
CoREST-HDAC complex |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222121 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11171972 |
Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST Is a Component of an HDAC1/2 Complex. p40 is a Sox-like protein, p110b contains homology to polyamine oxidases, p110a is ZNF217, an eight-zinc finger protein, and p80 is a hypothetical protein of unknown function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC1 | form complex
binding
|
CoREST-HDAC complex |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11171972 |
Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST Is a Component of an HDAC1/2 Complex. p40 is a Sox-like protein, p110b contains homology to polyamine oxidases, p110a is ZNF217, an eight-zinc finger protein, and p80 is a hypothetical protein of unknown function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CoREST-HDAC complex | down-regulates quantity by repression
transcriptional regulation
|
SCN3A |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268542 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16140033 |
This suggests that the HDACs in the LSD1 complex are likely to function upstream of CoREST/LSD1, generating a hypoacetylated histone substrate, which can then be better recognized by CoREST/LSD1. Further supporting this model, we found that inhibition of HDAC activity by TSA resulted in derepression of two LSD1 target genes, the human neuronal-specific sodium channel (SCN) genes, SCNA2 and SCNA3 (Figure 1H). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CoREST-HDAC complex