+ |
PKA | down-regulates activity
phosphorylation
|
TRPC5 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273790 |
Ser794 |
SGGARAKsKSVSFNL |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
21734191 |
Together, these results suggest that TRPC5 is directly phosphorylated by G(s)/cAMP/PKA at positions S794 and S796. These inhibitory effects were blocked by the protein kinase A (PKA) inhibitors, KT-5720 and H-89, as well as by two point mutations at consensus PKA phosphorylation sites on TRPC5 (S794A and S796A). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276340 |
Ser794 |
SGGARAKsKSVSFNL |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
21734191 |
We show that TRPC5 channels may become directly phosphorylated by PKA at serine residues 794 and 796, and that this phosphorylation abolishes the receptor-operated nonselective cation current mediated by TRPC5 channels in HEK-293 cells. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276339 |
Ser796 |
GARAKSKsVSFNLGC |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
21734191 |
We show that TRPC5 channels may become directly phosphorylated by PKA at serine residues 794 and 796, and that this phosphorylation abolishes the receptor-operated nonselective cation current mediated by TRPC5 channels in HEK-293 cells. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273789 |
Ser796 |
GARAKSKsVSFNLGC |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
21734191 |
Together, these results suggest that TRPC5 is directly phosphorylated by G(s)/cAMP/PKA at positions S794 and S796. These inhibitory effects were blocked by the protein kinase A (PKA) inhibitors, KT-5720 and H-89, as well as by two point mutations at consensus PKA phosphorylation sites on TRPC5 (S794A and S796A). |
|
Publications: |
4 |
Organism: |
Homo Sapiens |