| + |
PKA | down-regulates activity
phosphorylation
|
TRPC5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276340 |
Ser794 |
SGGARAKsKSVSFNL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21734191 |
We show that TRPC5 channels may become directly phosphorylated by PKA at serine residues 794 and 796, and that this phosphorylation abolishes the receptor-operated nonselective cation current mediated by TRPC5 channels in HEK-293 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273790 |
Ser794 |
SGGARAKsKSVSFNL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21734191 |
Together, these results suggest that TRPC5 is directly phosphorylated by G(s)/cAMP/PKA at positions S794 and S796. These inhibitory effects were blocked by the protein kinase A (PKA) inhibitors, KT-5720 and H-89, as well as by two point mutations at consensus PKA phosphorylation sites on TRPC5 (S794A and S796A). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276339 |
Ser796 |
GARAKSKsVSFNLGC |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21734191 |
We show that TRPC5 channels may become directly phosphorylated by PKA at serine residues 794 and 796, and that this phosphorylation abolishes the receptor-operated nonselective cation current mediated by TRPC5 channels in HEK-293 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273789 |
Ser796 |
GARAKSKsVSFNLGC |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21734191 |
Together, these results suggest that TRPC5 is directly phosphorylated by G(s)/cAMP/PKA at positions S794 and S796. These inhibitory effects were blocked by the protein kinase A (PKA) inhibitors, KT-5720 and H-89, as well as by two point mutations at consensus PKA phosphorylation sites on TRPC5 (S794A and S796A). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates quantity
phosphorylation
|
TRPC5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277823 |
Ser794 |
SGGARAKsKSVSFNL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21734191 |
Together, these results suggest that TRPC5 is directly phosphorylated by G(s)/cAMP/PKA at positions S794 and S796. These inhibitory effects were blocked by the protein kinase A (PKA) inhibitors, KT-5720 and H-89, as well as by two point mutations at consensus PKA phosphorylation sites on TRPC5 (S794A and S796A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKA | down-regulates quantity
phosphorylation
|
TRPC5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277824 |
Ser796 |
GARAKSKsVSFNLGC |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21734191 |
Together, these results suggest that TRPC5 is directly phosphorylated by G(s)/cAMP/PKA at positions S794 and S796. These inhibitory effects were blocked by the protein kinase A (PKA) inhibitors, KT-5720 and H-89, as well as by two point mutations at consensus PKA phosphorylation sites on TRPC5 (S794A and S796A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |