Summary

Name ACSL5
Full Name Long-chain-fatty-acid--CoA ligase 5
Synonyms Long-chain acyl-CoA synthetase 5, LACS 5 | ACS5, FACL5
Primary ID Q9ULC5
Links - -
Type protein
Relations 2
Pathways Fatty Acid Synthesis
Function Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.

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Relations

Regulator Mechanism target score ℹ
+ ACSL5down-regulates quantity img/direct_inhibition.png chemical modification long-chain fatty acid anion 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ ACSL5up-regulates quantity img/direct-activation.png chemical modification long-chain fatty acyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis