Summary

Name INO80
Full Name Chromatin-remodeling ATPase INO80
Synonyms hINO80, INO80 complex subunit A, Putative DNA helicase INO80 complex homolog 1 | INO80A, INOC1, KIAA1259
Primary ID Q9ULG1
Links - -
Type protein
Relations 1
Function ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820).

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Relations

Regulator Mechanism target score ℹ
+ INO80form complex img/form-complex.png binding INO80 complex 0.736
Publications: 1 Organism: Homo Sapiens