Summary

Name MMP17
Full Name Matrix metalloproteinase-17
Synonyms MMP-17, Membrane-type matrix metalloproteinase 4, MT-MMP 4, MTMMP4, Membrane-type-4 matrix metalloproteinase, MT4-MMP, MT4MMP | MT4MMP
Primary ID Q9ULZ9
Links - -
Type protein
Relations 2
Function Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

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Relations

Regulator Mechanism target score
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/indirect-activation.png ECM_disassembly 0.7
Publications: 1