Summary

Name ECM
Primary ID SIGNOR-ST20
Type stimulus
Description Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation, and are vital for maintaining normal homeostasis.(PMID:26562801 )
Relations 45
Pathways Integrin Signaling, YAP/TAZ regulation

Viewer

Relations

Regulator Mechanism target score
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png A5/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png AX/b2 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png AD/b2 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png A4/b7 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png A1/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png AE/b7 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png Av/b5 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png AM/b2 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png Av/b6 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png A6/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates img/direct-activation.png A9/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png Av/b8 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png A2/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png A4/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png Av/b3 integrin 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates img/direct-activation.png A11/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png A6/b4 integrin 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates img/direct-activation.png A10/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png Av/b2 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png AL/b2 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png A8/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png A3/b1 integrin 0.7
Publications: 1 Organism: Homo Sapiens