Relation Results

Summary

Name ADAMTS5
Full Name A disintegrin and metalloproteinase with thrombospondin motifs 5
Synonyms ADAM-TS 5, ADAM-TS5, ADAMTS-5, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2 | ADAMTS11, ADMP2
Primary ID Q9UNA0
Links - -
Type protein
Relations 2
Function Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix ( ...
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Type: Score: Layout: SPV 
0.7560.267ADAMTS5ACANSIRT1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ADAMTS5down-regulates quantity by destabilization img/direct_inhibition.png cleavage ACAN 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-266985 Glu392 PRNITEGeARGSVIL Homo sapiens
pmid sentence
Aggrecan Degradation in Human Cartilage Evidence for both Matrix Metalloproteinase and Aggrecanase Activity in Normal, Osteoarthritic, and Rheumatoid Joints|Stromelysin-1 (MMP-3), as well as other MMPs, cleave aggrecan in the interglobular domain between Asn341 and Phe342 to generate a G1 fragment with the COOH terminus VDIPEN341 (11–13). This fragment has been isolated and identified by NH2-terminal sequence analysis from human OA cartilage (11). A second proteolytic activity identified as “aggrecanase” also cleaves aggrecan in the interglobular domain, but between Glu373 and Ala374 (19–24), generating a G1 fragment with a COOH terminus of NITEGE374
Publications: 1 Organism: Homo Sapiens
+ SIRT1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ADAMTS5 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-255140 Homo sapiens
pmid sentence
The inhibition of SIRT1 by siRNA induced OA-like gene expression changes, namely the significant down-regulation of aggrecan and up-regulation of COL10A1 and ADAMTS-5.
Publications: 1 Organism: Homo Sapiens
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