| + |
SIRT1 | down-regulates 
deacetylation
|
EP300 |
0.842 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182507 |
Lys1020 |
EERSTELkTEIKEEE |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19047049 |
Sirt1 induces deacetylation and repression of p300 itself (81). Mutational analysis demonstrated that sirt1 repression of p300 involves both lysine 1020 and lysine 1024 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182511 |
Lys1024 |
TELKTEIkEEEDQPS |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19047049 |
Sirt1 induces deacetylation and repression of p300 itself (81). Mutational analysis demonstrated that sirt1 repression of p300 involves both lysine 1020 and lysine 1024 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
SIRT1 | up-regulates activity 
deacetylation
|
AKT |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252456 |
Lys14 |
VKEGWLHkRGEYIKT |
Mus musculus |
|
| pmid |
sentence |
| 21775285 |
We show that Akt and PDK1 are acetylated at lysine residues in their pleckstrin homology domains, which mediate PIP(3) binding. Acetylation blocked binding of Akt and PDK1 to PIP(3), thereby preventing membrane localization and phosphorylation of Akt. Deacetylation by SIRT1 enhanced binding of Akt and PDK1 to PIP(3) and promoted their activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Heart |
| Pathways: | Acute Myeloid Leukemia, AMPK Signaling, FLT3-ITD in AML |
| + |
SIRT1 | up-regulates activity
deacetylation
|
AKT1 |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252445 |
Lys14 |
VKEGWLHkRGEYIKT |
Mus musculus |
|
| pmid |
sentence |
| 21775285 |
We show that Akt and PDK1 are acetylated at lysine residues in their pleckstrin homology domains, which mediate PIP(3) binding. Acetylation blocked binding of Akt and PDK1 to PIP(3), thereby preventing membrane localization and phosphorylation of Akt. Deacetylation by SIRT1 enhanced binding of Akt and PDK1 to PIP(3) and promoted their activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Heart |
| + |
SIRT1 | up-regulates activity
deacetylation
|
XPA |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258986 |
Lys215 |
QENREKMkQKKFDKK |
Homo sapiens |
|
| pmid |
sentence |
| 30327428 |
SIRT1 deacetylates XPA at residues K63, K67, and K215 to promote interactions with ATR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262293 |
Lys63 |
TGGMANVkAAPKIID |
Homo sapiens |
A-375 Cell |
| pmid |
sentence |
| 30327428 |
SIRT1 deacetylates XPA at residues K63, K67, and K215 to promote interactions with ATR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262294 |
Lys67 |
ANVKAAPkIIDTGGG |
Homo sapiens |
A-375 Cell |
| pmid |
sentence |
| 30327428 |
SIRT1 deacetylates XPA at residues K63, K67, and K215 to promote interactions with ATR |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates activity
deacetylation
|
RELA |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238817 |
Lys310 |
KRTYETFkSIMKKSP |
Homo sapiens |
NCI-H460 Cell |
| pmid |
sentence |
| 15152190 |
SIRT1 physically interacts with the RelA/p65 subunit of NF-kappaB and inhibits transcription by deacetylating RelA/p65 at lysine 310. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | down-regulates
deacetylation
|
TP53 |
0.814 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182515 |
Lys382 |
QSTSRHKkLMFKTEG |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19047049 |
Sirt1 has been shown to regulate cell fate in part by deacetylating the p53 protein at lysine 382 and inhibiting p53-mediated transcriptional activation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | up-regulates activity
deacetylation
|
NHLH2 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254830 |
Lys49 |
EEAEGDGkGGSRAAL |
Mus musculus |
|
| pmid |
sentence |
| 22169038 |
SIRT1 deacetylates the brain-specific helix-loop-helix transcription factor NHLH2 on lysine 49 to increase its activation of the MAO-A promoter |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
SIRT1 | down-regulates
deacetylation
|
SMAD7 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150595 |
Lys64 |
RAGCCLGkAVRGAKG |
Homo sapiens |
|
| pmid |
sentence |
| 17098745 |
Sirt1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (lys-64 and -70) on smad7. sirt1-mediated deacetylation of smad7 enhanced smad ubiquitination regulatory factor 1 (smurf1)-mediated ubiquitin proteasome degradation, which contributed to the low expression of smad7 in sirt1-overexpressing mesangial cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150599 |
Lys70 |
GKAVRGAkGHHHPHP |
Homo sapiens |
|
| pmid |
sentence |
| 17098745 |
Sirt1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (lys-64 and -70) on smad7. sirt1-mediated deacetylation of smad7 enhanced smad ubiquitination regulatory factor 1 (smurf1)-mediated ubiquitin proteasome degradation, which contributed to the low expression of smad7 in sirt1-overexpressing mesangial cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | up-regulates
phosphorylation
|
SIRT1 |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162314 |
Ser27 |
ADREAASsPAGEPLR |
Homo sapiens |
|
| pmid |
sentence |
| 20027304 |
Human sirt1 was phosphorylated by jnk1 on three sites: ser27, ser47, and thr530 and this phosphorylation of sirt1 increased its nuclear localization and enzymatic activity. Surprisingly, jnk1 phosphorylation of sirt1 showed substrate specificity resulting in deacetylation of histone h3, but not p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162318 |
Ser47 |
DGPGLERsPGEPGGA |
Homo sapiens |
|
| pmid |
sentence |
| 20027304 |
Human sirt1 was phosphorylated by jnk1 on three sites: ser27, ser47, and thr530 and this phosphorylation of sirt1 increased its nuclear localization and enzymatic activity. Surprisingly, jnk1 phosphorylation of sirt1 showed substrate specificity resulting in deacetylation of histone h3, but not p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162322 |
Thr530 |
YLSELPPtPLHVSED |
Homo sapiens |
|
| pmid |
sentence |
| 20027304 |
Human sirt1 was phosphorylated by jnk1 on three sites: ser27, ser47, and thr530 and this phosphorylation of sirt1 increased its nuclear localization and enzymatic activity. Surprisingly, jnk1 phosphorylation of sirt1 showed substrate specificity resulting in deacetylation of histone h3, but not p53. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
CDK2 | up-regulates activity
phosphorylation
|
SIRT1 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279513 |
Ser47 |
DGPGLERsPGEPGGA |
Homo sapiens |
|
| pmid |
sentence |
| 27991597 |
Sirt1 is in turn phosphorylated by Cdk2, which may further regulate its activity.|Taken together, these data demonstrate that Cdk2 deletion does not decrease Hif1\u03b1 expression induced by HX, and strongly suggests that the phosphorylation of Sirt1 at Ser47 by Cdk2 requires Sirt1 deacetylase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTOR | down-regulates activity
phosphorylation
|
SIRT1 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280047 |
Ser47 |
DGPGLERsPGEPGGA |
Homo sapiens |
|
| pmid |
sentence |
| 21471201 |
These results demonstrate that the inhibition of SIRT1 by mTOR fosters survival of DNA damage-induced prematurely senescent squamous cell carcinoma cells via Bfl-1/A1 in the absence of functional p53.|This process involved the mTOR-dependent phosphorylation of SIRT1 at serine 47, resulting in the inhibition of the deacetylase activity of SIRT1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
CyclinB/CDK1 | up-regulates
phosphorylation
|
SIRT1 |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216841 |
Ser540 |
HVSEDSSsPERTSPP |
Homo sapiens |
|
| pmid |
sentence |
| 19107194 |
We identified cyclinb/cdk1 as a cell cycle-dependent kinase that forms a complex with and phosphorylates sirt1. Mutation of two residues phosphorylated by cyclin b/cdk1 (threonine 530 and serine 540) disturbs normal cell cycle progression and fails to rescue proliferation defects in sirt1-deficient cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
SIRT1 |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182863 |
Ser540 |
HVSEDSSsPERTSPP |
Homo sapiens |
|
| pmid |
sentence |
| 19107194 |
We identified cyclinb/cdk1 as a cell cycle-dependent kinase that forms a complex with and phosphorylates sirt1. Mutation of two residues phosphorylated by cyclin b/cdk1 (threonine 530 and serine 540) disturbs normal cell cycle progression and fails to rescue proliferation defects in sirt1-deficient cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
STK11 | up-regulates activity
phosphorylation
|
SIRT1 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277322 |
Ser615 |
GEKNERTsVAGTVRK |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 34216621 |
Resveratrol promotes the binding between LKB1 and Sirt1, which we first reported, and this binding leads to LKB1-mediated phosphorylation of Sirt1 at three different serine residues in the C terminus of Sirt1. Mechanistically, LKB1-mediated phosphorylation increases intramolecular interactions in Sirt1, such as the binding of the C terminus to the deacetylase core domain, thereby eliminating DBC1 (Deleted in Breast Cancer 1, Sirt1 endogenous inhibitor) inhibition and promoting Sirt1-substrate interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277321 |
Ser669 |
EDDVLSSsSCGSNSD |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 34216621 |
Resveratrol promotes the binding between LKB1 and Sirt1, which we first reported, and this binding leads to LKB1-mediated phosphorylation of Sirt1 at three different serine residues in the C terminus of Sirt1. Mechanistically, LKB1-mediated phosphorylation increases intramolecular interactions in Sirt1, such as the binding of the C terminus to the deacetylase core domain, thereby eliminating DBC1 (Deleted in Breast Cancer 1, Sirt1 endogenous inhibitor) inhibition and promoting Sirt1-substrate interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277323 |
Ser732 |
EAINEAIsVKQEVTD |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 34216621 |
Resveratrol promotes the binding between LKB1 and Sirt1, which we first reported, and this binding leads to LKB1-mediated phosphorylation of Sirt1 at three different serine residues in the C terminus of Sirt1. Mechanistically, LKB1-mediated phosphorylation increases intramolecular interactions in Sirt1, such as the binding of the C terminus to the deacetylase core domain, thereby eliminating DBC1 (Deleted in Breast Cancer 1, Sirt1 endogenous inhibitor) inhibition and promoting Sirt1-substrate interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34216621 |
Furthermore, LKB1-mediated Sirt1 activation may also play physiological roles in the context of antiaging and anticancer.|Together, these results suggest that LKB1-dependent phosphorylation of Sirt1 is crucial for mitochondrial biogenesis and respiration through the activation of PGC-1\u03b1. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
CSNK2A1 |
phosphorylation
|
SIRT1 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184151 |
Ser659 |
FHGAEVYsDSEDDVL |
Homo sapiens |
|
| pmid |
sentence |
| 19236849 |
We demonstrate that sirt1 is a substrate for protein kinase ck2 both in vitro and in vivo. Both, deletion construct analyses and serine-to-alanine mutations identified sirt1 ser-659 and ser-661 as major ck2 phosphorylation sites that are phosphorylated in vivo as well. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184155 |
Ser661 |
GAEVYSDsEDDVLSS |
Homo sapiens |
|
| pmid |
sentence |
| 19236849 |
We demonstrate that sirt1 is a substrate for protein kinase ck2 both in vitro and in vivo. Both, deletion construct analyses and serine-to-alanine mutations identified sirt1 ser-659 and ser-661 as major ck2 phosphorylation sites that are phosphorylated in vivo as well. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | up-regulates activity
phosphorylation
|
SIRT1 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278473 |
Thr530 |
YLSELPPtPLHVSED |
Homo sapiens |
|
| pmid |
sentence |
| 20167603 |
DYRK1A and DYRK3 directly phosphorylate SIRT1 at Thr(522), promoting deacetylation of p53.|DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates quantity by expression 
transcriptional regulation
|
ABCB1 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255139 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 20713551 |
Overexpression of SIRT1 enhanced both FoxO reporter activity and nuclear levels of FoxO1. Protein expression of MDR1 and gene transcriptional activity were also up-regulated by SIRT1 overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates
deacetylation
|
FOXO |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252993 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15126506 |
Deacetylation of foxos involves binding of the nad-dependent deacetylase hsir2(sirt1). Accordingly, hsir2(sirt1)-mediated deacetylation precludes foxo inhibition through acetylation and thereby prolongs foxo-dependent transcription of stress-regulating genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
FLT3 | up-regulates quantity by stabilization
post transcriptional regulation
|
SIRT1 |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261555 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26049753 |
SIRT1 protein but not mRNA expression is increased in CD34+ cells from FLT3-ITD positive AML patients compared to FLT3 wild-type AML patients |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
STK4 | down-regulates activity
phosphorylation
|
SIRT1 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21212262 |
We found that MST1 increases p53 acetylation and transactivation by inhibiting the deacetylation of Sirtuin 1 (Sirt1) and its interaction with p53 and that Sirt1 can be phosphorylated by MST1 leading to the inhibition of Sirt1 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Starvation | up-regulates activity
|
SIRT1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261951 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15744310 |
We show here that the Sir2 homologue, SIRT1—which modulates ageing in several species —controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1α. A nutrient signalling response that is mediated by pyruvate induces SIRT1 protein in liver during fasting. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| Pathways: | AMPK Signaling |
| + |
SIRT1 | down-regulates quantity by destabilization
deacetylation
|
FOXO1 |
0.82 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217975 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
DYRK3 | up-regulates activity
phosphorylation
|
SIRT1 |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279705 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20167603 |
DYRK1A and DYRK3 directly phosphorylate SIRT1 at Thr (522), promoting deacetylation of p53.|DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates activity
deacetylation
|
XBP1 (isoform 2) |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260430 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20955178 |
P300 increases the acetylation and protein stability of XBP1s, and enhances its transcriptional activity, whereas SIRT1 deacetylates XBP1s and inhibits its transcriptional activity.. The mRNA encoding the active spliced form of XBP1 (XBP1s) is generated from the unspliced form by IRE1 (inositol-requiring enzyme 1) during the UPR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates activity
deacetylation
|
FOXO1 |
0.82 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253509 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22395773 |
SIRT1 controls the acetylation of FOXO transcription factors, which are important regulators of lipid and glucose metabolism as well as stress response. On the other hand, SIRT1 can also stimulate the gluconeogenic transcriptional program by deacetylating and activating FOXO1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
SIRT1 | up-regulates activity
deacetylation
|
PPARGC1A |
0.809 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209962 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
AMPK can directly phosphorylate PGC-1a at Thr177 and Ser538 in in vitro assays PGC-1a phosphorylation might not directly affect its intrinsic coactivation activity, but, rather, release it from its repressor protein p160myb [79] and/or allow deacetylation and subsequent activation by SIRT1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217963 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 SIRT1 activation has been reported to increase dramatically endurance exercise through the activation of PGC-1_ in muscle, which stimulates fatty acid oxidation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | AMPK Signaling, Circadian clock |
| + |
SIRT1 | up-regulates
deacetylation
|
CRTC1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191568 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22179316 |
Sirt1 deacetylates and activates torc1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
PRKAA1 | down-regulates activity
phosphorylation
|
SIRT1 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280076 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26363315 |
Previous studies have reported that AMP-activated protein kinase phosphorylates and inactivates SIRT1, resulting in increased p53 acetylation in liver cancer [ xref , xref ]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates quantity by expression
transcriptional regulation
|
SOD2 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251763 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20089851 |
SIRT1 deacetylates and activates the FOXOs under oxidative stress, thereby inducing Mn-SOD expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates 
|
FOXO |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252997 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
CHFR | down-regulates quantity
ubiquitination
|
SIRT1 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27883020 |
CHFR binds to and ubiquitylates SIRT1, leading to its proteasomal degradation.|CHFR ubiquitylates and promotes the proteasomal degradation of SIRT1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267285 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates
deacetylation
|
FOXO4 |
0.756 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124714 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15126506 |
Deacetylation of foxos involves binding of the nad-dependent deacetylase hsir2(sirt1). Accordingly, hsir2(sirt1)-mediated deacetylation precludes foxo inhibition through acetylation and thereby prolongs foxo-dependent transcription of stress-regulating genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21633182 |
Interestingly, SIRT1 suppresses PPARγ but activates PGC-1α , and thus affects the clock network through multiple mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
SIRT1 | up-regulates quantity by expression
transcriptional regulation
|
HYOU1 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255143 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 22564731 |
Our results indicate a novel mechanism by which SIRT1 regulates ER stress by overexpression of ORP150, and suggest that SIRT1 ameliorates palmitate-induced insulin resistance in HepG2 cells via regulation of ER stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
resveratrol | up-regulates activity
chemical activation
|
SIRT1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238786 |
|
|
in vitro |
|
| pmid |
sentence |
| 12939617 |
We show that the potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD(+), and increases cell survival by stimulating SIRT1-dependent deacetylation of p53 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SIRT1 | down-regulates
deacetylation
|
FOXL2 |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182306 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19010791 |
We find that foxl2 activity is repressed by the sirt1 deacetylase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP22 | up-regulates quantity by stabilization
deubiquitination
|
SIRT1 |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26049753 |
USP22 expression was regulated by c-MYC and contributed to c-MYC mediated reduction in SIRT1 polyubiquitination and degradation. USP22 directly interacted with and removing polyubiquitin chains from SIRT1 to increase SIRT1 protein stabilization and expression. These results support a role for USP22 in MYC-mediated increase in SIRT1 protein stabilization, and indicate that FLT3-ITD, c-MYC and USP22 form an oncogenic network that enhances SIRT1 expression and activity in leukemic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | down-regulates quantity by repression
transcriptional regulation
|
ADAMTS5 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255140 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21337390 |
The inhibition of SIRT1 by siRNA induced OA-like gene expression changes, namely the significant down-regulation of aggrecan and up-regulation of COL10A1 and ADAMTS-5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates quantity by repression
transcriptional regulation
|
COL10A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255141 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21337390 |
The inhibition of SIRT1 by siRNA induced OA-like gene expression changes, namely the significant down-regulation of aggrecan and up-regulation of COL10A1 and ADAMTS-5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates quantity
transcriptional regulation
|
PPARGC1A |
0.809 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238790 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19553684 |
Collectively, these data indicate that SIRT1 controls PGC-1alpha gene expression in skeletal muscle and that MyoD is a key mediator of this action |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Circadian clock |
| + |
NAD(1-) | up-regulates activity
binding
|
SIRT1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10693811 |
Here we show that yeast and mouse Sir2 proteins are nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
SIRT1 | down-regulates activity
|
MYOD1 |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241963 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 12887892 |
Sir2 forms a complex with the acetyltransferase PCAF and MyoD and, when overexpressed, retards muscle differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SIRT1 | up-regulates quantity
chemical modification
|
nicotinamide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267964 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18662546 |
The SIRT1 catalytic reaction involves the breakdown of one NAD+ molecule for each deacetylated acetyl lysine and the generation of nicotinamide and O-acetyl-ADP-ribose. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates
deacetylation
|
NOTCH1 |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195333 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22223095 |
The acetylation marks on notch1-icd are removed by the deacetylase sirt1, suggesting that both deacetylation of notch1-icd and of histones inhibit notch signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | up-regulates
|
NCOR2 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253506 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22395773 |
In differentiated adipocyte cell lines, SIRT1 inhibits adipogenesis and enhances fat mobilization through lipolysis by suppressing the activity of PPARγ. SIRT1 achieves this by promoting the assembly of a corepressor complex, involving NCoR1 and SMRT, on the promoters of PPARγ target genes to repress their transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217878 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | up-regulates activity
deacetylation
|
FOXO3 |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122405 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
SIRT1 | down-regulates activity
deacetylation
|
FOXO3 |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122408 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217972 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | AMPK Signaling |
| + |
SIRT1 | up-regulates quantity by expression
transcriptional regulation
|
ACAN |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255142 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21337390 |
The inhibition of SIRT1 by siRNA induced OA-like gene expression changes, namely the significant down-regulation of aggrecan and up-regulation of COL10A1 and ADAMTS-5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates activity
deacetylation
|
FOXO |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252994 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | up-regulates
|
NCOR1 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253505 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22395773 |
In differentiated adipocyte cell lines, SIRT1 inhibits adipogenesis and enhances fat mobilization through lipolysis by suppressing the activity of PPARγ. SIRT1 achieves this by promoting the assembly of a corepressor complex, involving NCoR1 and SMRT, on the promoters of PPARγ target genes to repress their transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates activity
deacetylation
|
PLCG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275499 |
|
|
|
|
| pmid |
sentence |
| 24870244 |
The histone acetyltransferase GCN5 (general control non-repressed protein 5) acetylates PGC-1alpha and suppresses its transcriptional activity, whereas sirtuin 1 deacetylates and activates PGC-1alpha. |
|
| Publications: |
1 |
| + |
(S)-selisistat | down-regulates
chemical inhibition
|
SIRT1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates quantity by destabilization
binding
|
FOXO |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252996 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SRT1720 | up-regulates activity
chemical activation
|
SIRT1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-207114 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18046409 |
Here we describe the identification and characterization of small molecule activators of SIRT1 that are structurally unrelated to, and 1,000-fold more potent than, resveratrol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIC1 | down-regulates quantity by repression
transcriptional regulation
|
SIRT1 |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254419 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21277938 |
HIC1, via its BTB/POZ domain, forms a transcriptional repressor complex with Sirt1 [8] that binds directly to Sirt1 promoter itself, repressing its transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates quantity
deacetylation
|
CTNNB1 |
0.496 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256208 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 27776347 |
SIRT1 deacetylates β-catenin to promote its accumulation in the nucleus and thus induces the transcription of genes that block MSC adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | down-regulates quantity by destabilization
deacetylation
|
TP53 |
0.814 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261562 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25280219 |
SIRT1 overexpression was associated with down-modulation of p53 activity in FLT3-ITD AML CD34+ cells. SIRT1 can negatively regulate p53 by deacetylating several lysine sites |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | down-regulates activity
|
FOXO |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252995 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.809 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268033 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21633182 |
Interestingly, SIRT1 suppresses PPARγ but activates PGC-1α , and thus affects the clock network through multiple mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Circadian clock |
| + |
MYC | up-regulates quantity by stabilization
|
SIRT1 |
0.56 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261558 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26049753 |
Overexpression of c-MYC resulted in SIRT1 deubiquitination, whereas c-MYC knockdown led to decrease in SIRT1 protein stability and expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | down-regulates activity
binding
|
CLOCK/BMAL1 |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253722 |
|
|
|
|
| pmid |
sentence |
| 19299583 |
Using Per2:luciferase transcriptional reporter assays in HEK293 cells (Fig. 2C-E; S2), we show that inhibition of NAMPT by FK866 led to a significant increase in the CLOCK:BMAL1-driven transcription of the Per2:luciferase reporter (Fig. 2C), indicating that reduced NAMPT-mediated NAD+ biosynthesis released CLOCK:BMAL1 from the SIRT1-dependent suppression. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
FOXL2 | up-regulates quantity by expression
transcriptional regulation
|
SIRT1 |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182300 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19010791 |
Foxl2 can directly activate the transcription of sirt1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates quantity
chemical modification
|
2''-O-acetyl-ADP-D-ribose(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267963 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18662546 |
The SIRT1 catalytic reaction involves the breakdown of one NAD+ molecule for each deacetylated acetyl lysine and the generation of nicotinamide and O-acetyl-ADP-ribose. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCAR2 | down-regulates activity
binding
|
SIRT1 |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22735644 |
Here, we report that, in human cell lines, DNA damage triggered the phosphorylation of DBC1 on Thr454 by ATM (ataxia telangiectasia-mutated) and ATR (ataxia telangiectasia and Rad3-related) kinases. Phosphorylated DBC1 bound to and inhibited SIRT1, resulting in the dissociation of the SIRT1-p53 complex and stimulating p53 acetylation and p53-dependent cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miRNA-142-3p | down-regulates quantity by destabilization
post transcriptional regulation
|
SIRT1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279944 |
|
|
Homo sapiens |
Uveal Melanoma Cell |
| pmid |
sentence |
| 38663003 |
MiRNA-142-3p aggravates hydrogen peroxide-induced human umbilical vein endothelial cell premature senescence by targeting SIRT1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSAG2 | up-regulates activity
binding
|
SIRT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32761762 |
Here, we show that the previously undescribed CSAG2 protein is a direct activator of SIRT1. Biochemical studies revealed that CSAG2 directly binds to and stimulates SIRT1 activity toward multiple substrates. Importantly, CSAG2 enhances SIRT1‐mediated deacetylation of p53, inhibits p53 transcriptional activity, and improves cell survival in response to genotoxic stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | up-regulates
|
SIRT1 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184473 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19262508 |
The acute actions of ampk on lipid oxidation alter the balance between cellular nad+ and nadh, which acts as a messenger to activate sirt1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
4.0
SIRT1
- 
- 