| + |
AURKA | down-regulates activity 
phosphorylation
|
FAF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180887 |
Ser289 |
ITDVHMVsDSDGDDF |
Homo sapiens |
|
| pmid |
sentence |
| 18790738 |
This study reports that aurora-a (aur-a) phosphorylates fas-associated factor-1 (faf1) at ser-289 and ser-29 our findings support the negative feedback regulation of aur-a via phosphorylation of the death-promoting protein, faf1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180891 |
Ser291 |
DVHMVSDsDGDDFED |
Homo sapiens |
|
| pmid |
sentence |
| 18790738 |
This study reports that aurora-a (aur-a) phosphorylates fas-associated factor-1 (faf1) at ser-289 and ser-29 our findings support the negative feedback regulation of aur-a via phosphorylation of the death-promoting protein, faf1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | down-regulates activity
phosphorylation
|
FAF1 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250863 |
Ser289 |
ITDVHMVsDSDGDDF |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12832043 |
We previously identified the Fas-associated factor FAF1 as an in vitro substrate of protein kinase CK2 and determined Ser289 and Ser291 as phosphorylation sites.|Therefore we assume that CK2‐mediated FAF1 phosphorylation influences the nuclear localization of FAF1 | it implies that the major function of FAF1 might not be in the cytoplasm as an interacting partner of Fas. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250864 |
Ser291 |
DVHMVSDsDGDDFED |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12832043 |
We previously identified the Fas-associated factor FAF1 as an in vitro substrate of protein kinase CK2 and determined Ser289 and Ser291 as phosphorylation sites.|Therefore we assume that CK2‐mediated FAF1 phosphorylation influences the nuclear localization of FAF1 | it implies that the major function of FAF1 might not be in the cytoplasm as an interacting partner of Fas. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
IKBKE | down-regulates quantity by destabilization
phosphorylation
|
FAF1 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277618 |
Ser556 |
EREAIRLsLEQALPP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 30472208 |
Upon virus infection, the kinase IKKɛ directly phosphorylates FAF1 at Ser556 and triggers FAF1 de-aggregation. Moreover, Ser556 phosphorylation promotes FAF1 lysosomal degradation, consequently relieving FAF1-dependent suppression of MAVS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAF1 | down-regulates activity
binding
|
MAVS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277619 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 30472208 |
We find that the scaffold protein FAF1 forms aggregates that negatively regulate MAVS.FAF1 antagonizes the poly-ubiquitination and aggregation of MAVS by competing with TRIM31 for MAVS association. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FAF1
- 
- 