| + |
GSK3B | down-regulates activity 
phosphorylation
|
MACF1 |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264426 |
Ser7222 |
FRSRGRRsKPSSRAA |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264428 |
Ser7230 |
KPSSRAAsPTRSSSS |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264429 |
Ser7234 |
RAASPTRsSSSASQS |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264430 |
Ser7310 |
ADPKKSAsRPGSRAG |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264431 |
Ser7314 |
KSASRPGsRAGSRAG |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264432 |
Ser7318 |
RPGSRAGsRAGSRAS |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264433 |
Ser7322 |
RAGSRAGsRASSRRG |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264434 |
Ser7326 |
RAGSRASsRRGSDAS |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264435 |
Ser7330 |
RASSRRGsDASDFDL |
Homo sapiens |
Hair Follicle Bulge Stem Cell |
| pmid |
sentence |
| 21295697 |
We discovered that GSK3β, a kinase inhibited by Wnt signaling, directly phosphorylates ACF7, a > 500 kDa microtubule-actin crosslinking protein abundant in hair follicle stem cells (HF-SCs). We map ACF7's GSK3β sites to the microtubule-binding domain and show that phosphorylation uncouples ACF7 from microtubules. |
|
| Publications: |
9 |
Organism: |
Homo Sapiens |
| + |
MACF1 | down-regulates activity 
|
GSK3B/Axin/APC |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228000 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16815997 |
In the absence of wnt, macf1 associated with a complex that contained axin, betBeta-catenin, gsk3beta, and apc. Upon wnt stimulation, macf1 appeared to be involved in the translocation and subsequent binding of the axin complex to lrp6 at the cell membrane. Macf1 is involved in the translocation of the complex containing axin, Beta-catenin, and gsk3_ but not apc from the cytosol to the cell membrane, where axin and macf1 bind to lrp-5/6. Subsequently, gsk3_ is inactivated by phosphorylation, axin is degraded, and Beta-catenin is released and enters the nucleus, where it can activate the wnt-responsive genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MACF1 | down-regulates quantity by destabilization
|
GSK3B/Axin/APC |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227997 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16815997 |
In the absence of wnt, macf1 associated with a complex that contained axin, betBeta-catenin, gsk3beta, and apc. Upon wnt stimulation, macf1 appeared to be involved in the translocation and subsequent binding of the axin complex to lrp6 at the cell membrane. Macf1 is involved in the translocation of the complex containing axin, Beta-catenin, and gsk3_ but not apc from the cytosol to the cell membrane, where axin and macf1 bind to lrp-5/6. Subsequently, gsk3_ is inactivated by phosphorylation, axin is degraded, and Beta-catenin is released and enters the nucleus, where it can activate the wnt-responsive genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MACF1 | down-regulates quantity by destabilization
|
AXIN1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16815997 |
In the absence of wnt, macf1 associated with a complex that contained axin, betBeta-catenin, gsk3beta, and apc. Upon wnt stimulation, macf1 appeared to be involved in the translocation and subsequent binding of the axin complex to lrp6 at the cell membrane. Macf1 is involved in the translocation of the complex containing axin, Beta-catenin, and gsk3_ but not apc from the cytosol to the cell membrane, where axin and macf1 bind to lrp-5/6. Subsequently, gsk3_ is inactivated by phosphorylation, axin is degraded, and Beta-catenin is released and enters the nucleus, where it can activate the wnt-responsive genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MACF1 | down-regulates
|
GSK3B |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147451 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16815997 |
In the absence of wnt, macf1 associated with a complex that contained axin, betBeta-catenin, gsk3beta, and apc. Upon wnt stimulation, macf1 appeared to be involved in the translocation and subsequent binding of the axin complex to lrp6 at the cell membrane. Macf1 is involved in the translocation of the complex containing axin, Beta-catenin, and gsk3_ but not apc from the cytosol to the cell membrane, where axin and macf1 bind to lrp-5/6. Subsequently, gsk3_ is inactivated by phosphorylation, axin is degraded, and Beta-catenin is released and enters the nucleus, where it can activate the wnt-responsive genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MACF1 | up-regulates 
|
LRP6 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147457 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16815997 |
Macf1 appeared to be involved in the translocation and subsequent binding of the axin complex to lrp6 at the cell membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MACF1
- 
- 