Summary

Name AXIN1
Full Name Axin-1
Synonyms Axis inhibition protein 1, hAxin | AXIN
Primary ID O15169
Links - -
Type protein
Relations 50
Function Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation AXIN1 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AXIN1 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AXIN1 0.14
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation, binding AXIN1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AXIN1 0.14
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation AXIN1 0.49
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding APC 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AXIN1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding AXIN1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AXIN1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AXIN1 0.44
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AXIN1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AXIN1 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization AXIN1 0.48
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SMAD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AXIN1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RNF111 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation AXIN1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation, binding AXIN1 0.49
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png relocalization AXIN1 0.36
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding SMAD7 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png AXIN1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K1 0.28
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png AXIN1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination BMPR1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AXIN1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CSNK1D 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png AXIN1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization AXIN1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K4 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AXIN1 0.14
Publications: 1 Organism: Homo Sapiens