Summary

Name GSK3B/Axin/APC
Primary ID SIGNOR-C110
Type complex
Formed by AXIN1, APC, GSK3B
Relations 51
Pathways WNT Signaling, WNT Signaling and Myogenesis, Colorectal Carcinoma

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.22
Publications: 1 Organism: Mus Musculus
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.45
Publications: 10 Organism: Homo Sapiens
Tissue: Brain, Colonic Cancer Cell
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation PSEN1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ROR2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CSNK1D 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GSK3B/Axin/APC 0.37
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.45
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ form complex img/form-complex.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding, phosphorylation GSK3B/Axin/APC 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GSK3B/Axin/APC 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding GSK3B/Axin/APC 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney, Lung
+ down-regulates activity img/direct_inhibition.png binding GSK3B/Axin/APC 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png relocalization GSK3B/Axin/APC 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/indirect_inhibition.png GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GSK3B/Axin/APC 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png relocalization GSK3B/Axin/APC 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png dephosphorylation GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens